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Clinical Trial Summary

Patients who respond to anti-VEGF therapy but with refractory retinal and choroidal neovascularization diseases including neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion-Macular edema (RVO-ME).


Clinical Trial Description

Choroidal and retinal angiogenesis diseases are a group of diseases characterized by choroidal or retinal angiogenesis. These diseases are often correlated with the macular area, which may lead to significant visual loss. In this study, The IDLV vector is engineered to carry the VEGFA antibody gene. The gene is delivered to the RPE cells to express the VEGFA antibody which neutralizes the VEGFA activity in the posterior segment of the eye of individuals who have progressed to various forms of neovascular macular degeneration. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05099094
Study type Interventional
Source Shanghai BDgene Co., Ltd.
Contact Yujia Cai, PhD
Phone 17721291876
Email yujia.cai@bdgene.cn
Status Recruiting
Phase Early Phase 1
Start date November 25, 2021
Completion date September 2023

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