Diabetic Ketoacidosis Clinical Trial
Official title:
Acute and Long-term Neuroanatomical and Cognitive Evaluation of Adult Patients With First and Recurrent Episodes of Diabetic Ketoacidosis
The purpose of this study is to assess brain and memory changes in patients with uncontrolled diabetes (a condition called diabetic ketoacidosis (DKA))
Diabetic ketoacidosis (DKA) is a common and serious medical problem. Most cases occur when
patients forget or stop insulin injections. Some patients require frequent admissions to the
hospital with DKA after stopping insulin. Many patients do not know why they stop insulin
therapy. The investigators will test if patients with one or more episodes of DKA have poor
memory and brain changes that may lead to poor management.
In this study, the investigators will perform memory testing and brain images in subjects
with initial DKA episode and subjects with more than 3 episodes of DKA. The results will be
compared to subjects with diabetes and no history of DKA and healthy (non-diabetic) subjects.
Each subject with DKA will have an MRI and cognitive testing done shortly after hospital
discharge, 1 month, and 3 months after hospital discharge. Diabetic subjects without DKA and
healthy controls will only come in for a single baseline visit and have a MRI and cognitive
testing done.
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