Dexamethasone Clinical Trial
Official title:
Pilot Study of Methylprednisolone Replacement for Dexamethasone-induced Hiuup Patients
Dexamethasone is a potent synthetic member of the corticosteroid. It is given to cancer
patients undergoing chemotherapy to counteract emetic side effect and essential drug for the
chemotherapy-treated patients. Hiccup is common adverse effect of corticosteroid especially
on dexamethasone varying from 3% to 60% of given patients. Discontinuance of dexamethasone
relieves most hiccupping cases, but vomiting/nausea rates increase. It is not clear whether
hiccup side effect is limited to the dexamethasone only or other corticosteroid group.
Methylprednisolone, synthetic corticosteroid as similar as dexamethasone, could be
considered as antiemetic agent for the patients with receiving chemotherapy. The
investigators perform this pilot study under hypothesis that replacing dexamethasone with
methylprednisolone could maintain antiemetic role and prevent hiccup.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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