Propolis in Reducing Dentin Hypersensitivity

Status Completed

Clinical Trial Summary

Objective: This randomized, double-blind, parallel, placebo-controlled clinical trial aims to evaluate the effect of propolis with two distinct concentrations (10% and 15%), and the impact on volunteers' quality of life. Materials and methods: Volunteers meeting the inclusion and exclusion criteria will be randomized and allocated into three groups: Group 1- placebo - toothpaste without active ingredient, Group 2- toothpaste with 10% propolis and Group 3. - toothpaste with 15% propolis. Number of teeth will be used as sample unit, totaling 22 teeth per group. Volunteers will receive oral hygiene instruction with guidance to brush their teeth three times a day with toothpaste corresponding to the groups in which they will be allocated for 30 days. The evaluation of dentin hypersensitivity will be performed with three (3) evaluation times: baseline (immediately before the beginning of treatment), 15 and 30 days, through tactile and evaporative stimuli, using the visual analog scale (VAS). The self-reported evaluation of the volunteers will be done through a questionnaire before the beginning and after one month with the completion of the research to determine the impact of treatment on their quality of life. The data regarding HD in VAS, if present normal distribution, will be used Two-way analysis of variance (ANOVA) with Tukey's post hoc for comparison between treatments. However, if the data show anormal distribution, Friedman to compare the different times in the same group (intra group), and Kruskal Wallis to make the comparison between groups (inter group). To evaluate the QEHD ordinal data, Wilcoxon and Mann-Whitney tests will be used. Bioestat 5.3 (Belém, Pará, Brazil) will be used, considering an alpha level of 5%.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05083052
Study type	Interventional
Source	Universidade Federal do Para
Contact
Status	Completed
Phase	N/A
Start date	November 5, 2020
Completion date	December 20, 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02753075` - A Study in Dentinal Hypersensitivity (DH) Participants to Assess the Efficacy of an Occluding Dentifrice.	N/A
Completed	`NCT06045026` - A Real-World Evidence Study Evaluating Oral Health Related Quality Of Life With Use Of A Stannous Fluoride Anti-Sensitivity Toothpaste For Dentin Hypersensitivity Management	N/A
Completed	`NCT02861664` - Assessment of the Efficacy of an Experimental Occlusion Technology Dentifrice in Dentinal Hypersensitivity	N/A
Completed	`NCT02542943` - Efficacy of Two Experimental Oral Rinses in Providing Long Term Relief From Dentinal Hypersensitivity	N/A
Completed	`NCT02226562` - Clinical Study Investigating the Efficacy of a Mouthwash in Providing Long Term Relief From Dentinal Hypersensitivity	Phase 2
Completed	`NCT02919202` - Clinical Trial to Compare the Efficacy of a Fluoride Gel and a Dental Bonding Agent in Treatment of Tooth Sensitivity	N/A
Not yet recruiting	`NCT04485299` - Clinical Assessment of Bifluorid 10 vs Varnish Fluoride on The Exposed Hypersensitive Cervical Dentin in Adult Patient	Phase 2/Phase 3
Completed	`NCT02931734` - Assessment of Different Protocols for Cervical Dentin Hypersensitivity Treatment	N/A
Completed	`NCT02923895` - To Investigate the Efficacy of an Occluding Dentifrice in Dentinal Hypersensitivity (DH)	Phase 4
Withdrawn	`NCT03361774` - A Clinical Method Development Study to Characterise The Efficacy of a Dentifrice For The Relief Of Dentin Hypersensitivity	Phase 2
Completed	`NCT02924350` - The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity (DH)	N/A
Active, not recruiting	`NCT06150573` - A Study Assessing the Effects of an Experimental Dentifrice in Maintaining Tooth Color Following Tooth Bleaching	N/A
Completed	`NCT02937623` - To Evaluate the Efficacy of an Experimental Dissolvable Strip in Rapidly Relieving Dentinal Hypersensitivity (DH)	N/A
Completed	`NCT02612064` - The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity	N/A
Completed	`NCT02293044` - A Study to Evaluate the Safety and Efficacy of an Oxalate Strip on Adjacent Teeth With Dentinal Hypersensitivity	N/A
Completed	`NCT02128633` - Effectiveness of a Homecare Dentin Hypersensitivity Gel	Phase 2/Phase 3
Completed	`NCT03310268` - A Clinical Study to Evaluate a Stannous Fluoride Toothpaste for the Relief of Dentinal Hypersensitivity	N/A
Completed	`NCT05750745` - A Clinical Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste for the Relief of Dentine Hypersensitivity in a Chinese Population	N/A
Not yet recruiting	`NCT06417580` - Effect of Pregabalin Gel in Controlling Cervical Dentin Hypersensitivity	Phase 2
Completed	`NCT02752958` - Impact of Long Term Management of Dentine Hypersensitivity (DH) With a Daily Use Anti-sensitivity Toothpaste on the Quality of Life Related to Oral Health	N/A