Dentine Tubule Occlusion Assessment in a Modified in Situ Model

Status Completed

Clinical Trial Summary

This will be a single centre, single blind, randomized, three treatment, three period crossover design, modified, in situ, study in healthy participants. In this in situ model the tubule occlusion properties of dentifrices will be evaluated by comparing an experimental dentifrice formulation to a regular fluoride dentifrice and a negative control (mineral water) over a ten day period.

Clinical Trial Description

This modified in situ model study will evaluate the mode-of-action of an experimental dentifrice containing stannous fluoride to occlude tubules compared to a regular fluoride dentifrice and a negative control (mineral water). The study treatments will be administered for a total of 10 days, with participants wearing two appliances in their mouth that will hold samples of dentine. The dentine samples will be examined after 1, 4, 8 and 10 days of treatment using scanning electron microscopy (SEM) and the resulting images graded for the amount of occlusion. In addition, the robustness of any occlusion generated by the treatments will be tested by exposing the dentine samples to an acid challenge (orange juice) after 9 and 10 days treatment. ;

Study Design

Related Conditions & MeSH terms

Dentin Sensitivity

Clinical Trial Details

NCT number	NCT02768194
Study type	Interventional
Source	GlaxoSmithKline
Contact
Status	Completed
Phase	N/A
Start date	July 6, 2016
Completion date	September 21, 2016

View Details

See also
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