Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT06025084 |
| Other study ID # |
Fadia Ali El-Sayed Shosha |
| Secondary ID |
|
| Status |
Completed |
| Phase |
Phase 1
|
| First received |
|
| Last updated |
|
| Start date |
December 1, 2022 |
| Est. completion date |
March 30, 2023 |
Study information
| Verified date |
August 2023 |
| Source |
Egymedicalpedia |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
Dentin hypersensitivity is one of the most commonly occurring clinical dental conditions
which is characterized by short and sharp pain which arises from exposed dentin in response
to external stimuli, which typically are thermal, evaporative, tactile, osmotic or chemical.
Hypersensitive dentin is mostly found in buccal tooth areas, in which enamel is missing
because of abrasion, attrition, or erosion. The most generally accepted theory regarding the
mechanism of dentin hypersensitivity is the hydrodynamic theory. It proposes that a
pain-provoking stimulus increases the flow of the dentinal tubular fluid and consequently,
stimulates the nerves around the odontoblasts, leading to dentin hypersensitivity.
Description:
Dentin desensitizing products, containing agents such as fluoride, strontium salts, oxalate,
glutaraldehyde and bioactive glass, are employed to treat dentin hypersensitivity.
Based on the hydrodynamic theory, there are two main strategies for the treatment of dentin
hypersensitivity as: (1) occluding the dentinal tubules to reduce the fluid flow, and (2)
decreasing the excitability of the intradental nerve.
Although these products and agents were reported to be effective, short durability and poor
effectiveness were often exhibited. The therapeutic effects of these desensitizing products
were short lived on account of daily tooth brushing or drinking of acidic beverages and the
occlusion effects were sometimes incomplete. Owing to these drawbacks, the use of
nanomaterials as dentin occluding material has been predicted to be the future of treating
DH.
Amorphous Calcium Phosphate (ACP) has the potential to remineralize the structure of tooth.
ACP is a soluble calcium phosphate compound that discharges calcium and phosphate ions to
change to apatite and remineralize the tooth structure when it comes in contact with saliva.
Forming on the enamel and within the dental tubules, ACP provides a reservoir of phosphate
and calcium ions in the saliva Casein phospho-peptide (CPP) is a milk-derived protein that
joins to the tooth's biofilm and is applied to stabilize ACP. In recent years,
remineralization products used CPP as a vehicle to deliver and preserve a super saturation
state of ACP near the surface of tooth. A previous study showed that the application of
(CPP-ACP) containing agents as GC tooth mousse and MI paste plus can reduce dentin
permeability by occluding dentin tubules. It revealed that these materials can be effective
for treatment of dentin hypersensitivity.
Recently, there has been a renewed interest in developing materials with a bioactive
potential that could block the exposed dentinal tubules and subsequently reduce the fluid
flow within the tubules. Eggshells (EBs) have been investigated in recent years for their
remineralization capabilities. EB has rich bioavailable calcium content in the form of
carbonates and oxides. It contains 94% calcium carbonate, 1% calcium phosphate, 1% magnesium
carbonate, and 4% organic matter. In addition, eggshell provides a cost-effective, renewable,
and sustainable source of material for EnHAp. A previous study revealed that eggshell powder
is predicted to be the future of tooth remineralization and highly effective in occluding
dentinal tubules and reducing dentin hypersensitivity.
Titanium dioxide is one of the few materials that classified as bioactive meaning that it
enhances bone growth and stable bone bonding with dental implants via precipitation of
hydroxyapatite on its surface
