Healing Abutment Materials on Matrix Metalloproteinase-8 Level in Peri-implant Crevicular Fluid

Dental Implants Clinical Trial

Official title:

Effect of Two Different Healing Abutment Materials on Matrix Metalloproteinase-8 Level in Peri-implant Crevicular Fluid (a Randomised Clinical Trial)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06034132
• Other study ID #: Implants_2022_MP8
• Status: Completed
• Phase: N/A
• Start date: January 1, 2023
• Est. completion date: June 15, 2023

Study information

• Verified date: September 2023
• Source: Alexandria University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Numerous materials are nowadays used in the fabrication of healing abutments to be used for dental implants. soft tissue response to different healing abutment materials is still to be unraveled. the Aim of this study is to compare the soft tissue response to titanium stock healing abutments to customized composite healing abutments through assessing the level of matrix metalloproteinase-8 in the peri-implant crevicular fluid

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: June 15, 2023
• Est. primary completion date: June 15, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 25 Years to 65 Years

Eligibility

Inclusion Criteria:

• Patients with no systemic and/or oral health disease

• absence of any lesions in the oral cavity

• wide band of keratinized tissue more than 1mm at implant site

Exclusion Criteria:

• smoking more than 20 cigarettes per day

• localized radiation therapy of the oral cavity,

• antitumor chemotherapy, liver diseases, blood diseases, kidney diseases, immunosuppressed patients, patients taking corticosteroids, pregnancy, inflammatory and autoimmune diseases of the oral cavity

Related Conditions & MeSH terms

• Dental Implants

Intervention

Other:
• Stock healing abutments
2ND stage surgery will be performed and stock healing abutment were placed
• Compoiste healing abutments
2ND stage surgery will be performed and composite healing abutment were placed

Locations

Country	Name	City	State
Egypt	Alexandria Faculty of Dentistry	Alexandria

Sponsors (1)

Lead Sponsor	Collaborator
Alexandria University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in MMP8 levels	Measuring MMP-8 level around composite and titanium healing abutments with ELISA kit	at 2 weeks and 4 weeks
Secondary	Change in gingival condition	Modified gingival index was used to assess gingival condition The MGI uses a rating score between 0 and 4 0 = absence of inflammation; = mild inflammation; = mild inflammation; = moderate inflmmation; = severe inflammation	at 2 weeks and 4 weeks
Secondary	Change in gingival bleeding	Bleeding index will be recorded as present or absent	at 2 weeks and 4 weeks
Secondary	Change in plaque accumulation	Plaque index 0: No plaque is in the area adjacent to the gingiva. Plaque index 1: There is a plaque in the form of a thin film on the gingival margin.; Plaque index 2: There is a visible plaque in the gingival pocket and gingival margin.; Plaque index 3: There is a dense plaque in the gingival pocket and on the gingival margin.	at 2 weeks and 4 weeks