Dental Caries Clinical Trial
Official title:
A Double Blind, Randomized, Cross Over Designed Trial of Fluoride Prevention by Double Rinse With Calcium and Fluoride
Aim: to determine the optimal Ca2+ concentration with 905 ppm F as NaF. Study design:
Experimental study in 10 volunteers. Single blind mouth rinse with calcium lactate solution
(150; 75; 0 mM Ca-lactate) is immediately followed by a standard fluoride rinse.
Procedure: Rinses are performed in the evening. The rinse combinations are given in a random
order, and the subjects are unaware of the sequence. At least 3 days separates the use of
each rinse. Dosage: 20 mL and 1 minute rinse with each solution.
Saliva samples: Twelve hours after rinsing, unstimulated saliva samples are collected by
expectoration.
Analysis: The fluoride concentration in saliva samples are analysed Statistics and data
handling: Fluoride in saliva 12 hours after rinsing are examined by one-way ANOVA, repeated
measures design.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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