Dengue Clinical Trial - Expansion of a Dengue-1 Live Virus Human Challenge

Status Completed

Clinical Trial Summary

To evaluate the effectiveness of candidate dengue vaccine formulations, it is prudent to develop an appropriate challenge model. This study supports the expansion of the data set of the current Dengue 1 Live Virus Human Challenge (DENV-1-LVHC) model to produce uncomplicated dengue-like illness.

Clinical Trial Description

This is an expansion of a previous study conducted under NCT02372175. In this study up to nine healthy subjects between 18 and 45 years old will be inoculated with Dengue 1 Live Virus Human Challenge (DENV-1-LVHC) at a dose used in the previous study. Subjects will be closely monitored for the first 28 days with continued follow up through 6 months. Clinical and laboratory parameters, viremia and antibody levels will be assess. The goal is to expand the data set of symptoms produced by uncomplicated dengue-like illness. ;

Study Design

Related Conditions & MeSH terms

Dengue

Clinical Trial Details

NCT number	NCT03869060
Study type	Interventional
Source	State University of New York - Upstate Medical University
Contact
Status	Completed
Phase	Phase 1
Start date	March 11, 2019
Completion date	September 20, 2019

View Details

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