Dementia Clinical Trial
— WOTBOfficial title:
Words on the Brain: Can Reading Rehabilitation for Age-Related Vision Impairment Improve Cognitive Functioning?
Verified date | March 2023 |
Source | Université de Montréal |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Age-related vision impairment and dementia both become more prevalent with increasing age. Research into the mechanisms of these conditions has proposed that some of their causes (e.g., macular degeneration/glaucoma and Alzheimer's disease) could be symptoms of an underlying common cause, or may be equally linked to a multifactorial context in frailty and aging. Research into sensory-cognitive aging has provided preliminary data that sensory decline may be linked to the progression of dementia through the concept of sensory deprivation. Preliminary data in hearing loss rehabilitation support the idea that improved hearing may have a beneficial effect on cognitive functioning; however, there are to date no data available to examine whether low vision rehabilitation, specifically for reading, could have an equally protective or beneficial effect on cognitive health. The present proposal aims to fill this gap.
Status | Terminated |
Enrollment | 38 |
Est. completion date | March 28, 2023 |
Est. primary completion date | March 28, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 65 Years and older |
Eligibility | Inclusion Criteria: 1. Able to communicate in either English or French 2. Impairment of central vision, affecting acuity due to any diagnosis 3. Visual acuity in the better eye with best standard correction of 20/60 or less 4. Potential benefit from magnification or other reading rehabilitation interventions, as determined by rehabilitation professional. 5. Client dossier with one of the partnering rehabilitation agencies. Exclusion Criteria: 1. Complete blindness 2. Inability to communicate verbally 3. Inability to independently give informed written consent |
Country | Name | City | State |
---|---|---|---|
Canada | Institut Nazareth et Louis-Braille du CISSS de la Montérégie-Centre | Longueuil | Quebec |
Canada | Centre de réadaptation Lethbridge-Layton-Mackay du CIUSSS du Centre-Ouest-de-l'Île-de-Montréal | Montreal | Quebec |
Lead Sponsor | Collaborator |
---|---|
Université de Montréal | Canadian Institutes of Health Research (CIHR), Fonds de la Recherche en Santé du Québec |
Canada,
Aubin, G., Phillips, N., Jaiswal, A., Johnson, A., Joubert, S., Bachir, V., Kehayia, E. & Wittich, W. (2023). Visual and cognitive functioning among older adults with low vision before vision rehabilitation, Frontiers in Psychology - Cognition, 14, 105895
Wittich W, Pichora-Fuller MK, Johnson A, Joubert S, Kehayia E, Bachir V, Aubin G, Jaiswal A, Phillips N. Effect of Reading Rehabilitation for Age-Related Macular Degeneration on Cognitive Functioning: Protocol for a Nonrandomized Pre-Post Intervention Study. JMIR Res Protoc. 2021 Mar 11;10(3):e19931. doi: 10.2196/19931. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Rey Auditory Verbal Learning Test (RAVLT) | Participants are verbally presented with a list of 15 words that they are asked to repeat and memorize, then recall immediately, and again recall them 15 minutes later. The score is the number of items recalled from 0 to 15, with higher scores indicating better recall. | 15 minutes | |
Primary | Letter Number Sequencing task | Participants are asked to speak out loud the first 13 letters of the alphabet and alternate them with consecutive numbers (e.g., 1 - A - 2 - B 3 -C ...). The score is the number of correct alternations between numbers and letter, from 0 to 26, with higher scores indicating better performance. | 2 minutes | |
Primary | Montreal Cognitive Assessment - full or blind version | Participants are asked to complete the visual and auditory items of this cognitive screening measure. The Blind versions (no visual items is utilized for persons whose vision is too impaired to see the pictograms). The score is the total number of items completed correctly, ranging from 0 to 30 for the full version, and 0 to 22 for the Blind version, with higher scores indicating better outcomes | 4 minutes | |
Primary | 1-n-back task | Participants are asked to verbally repeat a string of numbers presented orally, while naming the previous item to the one just presented. The score is the total number of correct recalls, ranging from 0 to 25, with higher scores indicating better performance. | 3 minutes | |
Secondary | Minnesota Reading Test (MNRead) | Participants are asked to read individual sentences on an eye chart. The log score indicates reading acuity ranging from -0.1 to 1.0 with higher numbers indicating poorer acuity. | 2 minutes | |
Secondary | Depression, Anxiety and Stress Scale | A 21-item questionnaire that measures the self-reported perception of depression, anxiety and stress on its three sub-scales, respectively. Scores for each item are from 0 to 3. Higher scores indicate higher levels of perceived depression, anxiety and stress, ranging each from 0 to 21 for each sub-scale. | 5 minutes | |
Secondary | Canadian Digit Triplet Test | A test measuring speech-in-noise perception. Participants are presented with three spoken digits through a head-set, and are asked to then enter them on a keyboard. Correct repetition will increase background noise, while incorrect answers will decrease background noise. The outcome measure is the estimated threshold for the signal-to-noise ratio where a participant can still comprehend the spoken digits. More negative score ratios indicate more tolerance to noise, therefore indicating better performance | 4 minutes | |
Secondary | Magnetic Resonance Imaging (MRI) - for subset of participants | Cortical invasive scan to measure structure and volume of brain regions involved in reading and sensory processing. Participants will placed in a Magnetic Resonance Imaging scanner in order to obtain structural measurement of their cortical architecture. Participants are asked to remain still a possible during these scans; however, they are not required to be otherwise engaged in any activity or decision-making. Higher volume measures indicate that more cortical volume is allocated to specific brain regions. This does not necessarily imply a functional judgment on its capacity, but is an anatomical measure only. | 45 minutes |
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