Dementia Clinical Trial
Official title:
Connectomics in Psychiatric Classification
Verified date | May 2020 |
Source | Washington University School of Medicine |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Washington University Early Recognition Center is conducting a research study to examine brain functional connectivity and network patterns in participants with dementia.
Status | Completed |
Enrollment | 30 |
Est. completion date | September 5, 2019 |
Est. primary completion date | September 5, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 45 Years to 85 Years |
Eligibility |
Inclusion Criteria: - Ages 45-85 - Has consented to participate or has an LAR present that has consented to participate - DSM-5 diagnosis of Dementia Exclusion Criteria: - Any genetic disorder, such as cystic fibrosis or sickle cell disease - Multiple Sclerosis - Cerebral Palsy - Loss of consciousness for >30 minutes - Pregnancy - Hospitalization for stroke, brain aneurysm, brain hemorrhage, or subdural hematoma |
Country | Name | City | State |
---|---|---|---|
United States | Washington University School of Medicine | Saint Louis | Missouri |
Lead Sponsor | Collaborator |
---|---|
Washington University School of Medicine |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Hair sample for cortisol measurement | To see how cortisol levels can help characterize brain imaging findings | within one month of study enrollment | |
Primary | Magnetic Resonance Imaging (MRI) Brain Imaging | The current project aims to uncover latent, homogenous, connectivity phenotypes using neuroimaging tools, which are free from the limitations of traditional diagnostic boundaries, and which correlate with clinical characteristics. The investigator will use resting state functional connectivity MRI (rs-fcMRI), diffusion MRI (dMRI) and tract-based spatial statistics (TBSS) to identify brain signatures that cut across psychiatric disorders. | within one month of study enrollment | |
Secondary | DNA testing through saliva | Saliva samples will be collected from participants for DNA extraction and the development of lymphoblastoid cell lines. DNA is used for research purposes only, for studies assessing brain connectivity. | within one month of study enrollment |
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