Dementia Clinical Trial
Official title:
Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy
Verified date | November 2017 |
Source | University of Oxford |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Follow-up study within the Whitehall II study, selecting 800 participants for further neuropsychological, clinical and imaging (MRI) examinations to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.
Status | Completed |
Enrollment | 800 |
Est. completion date | June 30, 2017 |
Est. primary completion date | June 30, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - Member of Whitehall II cohort attending at UCL for phase 11 Exclusion Criteria: - Not suitable for MRI, travelling to Oxford, seriously physically ill |
Country | Name | City | State |
---|---|---|---|
United Kingdom | University of Oxford | Oxford | England |
Lead Sponsor | Collaborator |
---|---|
University of Oxford | University College, London |
United Kingdom,
Allan CL, Sexton CE, Filippini N, Topiwala A, Mahmood A, Zsoldos E, Singh-Manoux A, Shipley MJ, Kivimaki M, Mackay CE, Ebmeier KP. Sub-threshold depressive symptoms and brain structure: A magnetic resonance imaging study within the Whitehall II cohort. J — View Citation
Allan CL, Zsoldos E, Filippini N, Sexton CE, Topiwala A, Valkanova V, Singh-Manoux A, Tabak AG, Shipley MJ, Mackay C, Ebmeier KP, Kivimaki M. Lifetime hypertension as a predictor of brain structure in older adults: cohort study with a 28-year follow-up. B — View Citation
Filippini N, Zsoldos E, Haapakoski R, Sexton CE, Mahmood A, Allan CL, Topiwala A, Valkanova V, Brunner EJ, Shipley MJ, Auerbach E, Moeller S, Ugurbil K, Xu J, Yacoub E, Andersson J, Bijsterbosch J, Clare S, Griffanti L, Hess AT, Jenkinson M, Miller KL, Sa — View Citation
Griffanti L, Jenkinson M, Suri S, Zsoldos E, Mahmood A, Filippini N, Sexton CE, Topiwala A, Allan C, Kivimaki M, Singh-Manoux A, Ebmeier KP, Mackay CE, Zamboni G. Classification and characterization of periventricular and deep white matter hyperintensitie — View Citation
Heise V, Zsoldos E, Suri S, Sexton C, Topiwala A, Filippini N, Mahmood A, Allan CL, Singh-Manoux A, Kivimaki M, Mackay CE, Ebmeier KP. Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling olde — View Citation
Sexton CE, Zsoldos E, Filippini N, Griffanti L, Winkler A, Mahmood A, Allan CL, Topiwala A, Kyle SD, Spiegelhalder K, Singh-Manoux A, Kivimaki M, Mackay CE, Johansen-Berg H, Ebmeier KP. Associations between self-reported sleep quality and white matter in — View Citation
Suri S, Emir U, Stagg CJ, Near J, Mekle R, Schubert F, Zsoldos E, Mahmood A, Singh-Manoux A, Kivimaki M, Ebmeier KP, Mackay CE, Filippini N. Effect of age and the APOE gene on metabolite concentrations in the posterior cingulate cortex. Neuroimage. 2017 M — View Citation
Suri S, Topiwala A, Filippini N, Zsoldos E, Mahmood A, Sexton CE, Singh-Manoux A, Kivimaki M, Mackay CE, Smith S, Ebmeier KP. Distinct resting-state functional connections associated with episodic and visuospatial memory in older adults. Neuroimage. 2017 — View Citation
Topiwala A, Allan CL, Valkanova V, Zsoldos E, Filippini N, Sexton C, Mahmood A, Fooks P, Singh-Manoux A, Mackay CE, Kivimaki M, Ebmeier KP. Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort s — View Citation
Topiwala A, Allan CL, Valkanova V, Zsoldos E, Filippini N, Sexton CE, Mahmood A, Singh-Manoux A, Mackay CE, Kivimaki M, Ebmeier KP. Resilience and MRI correlates of cognitive impairment in community-dwelling elders. Br J Psychiatry. 2015 Nov;207(5):435-9. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Neuropsychological measure 1 | National Adult Reading Test (premorbid intellectual ability) | 2012-2016 | |
Primary | Neuropsychological measure 2 | Montreal Cognitive Assessment (MoCA) | 2012-2016 | |
Primary | Neuropsychological measure 3 | Rey Complex Figure copy and delayed recall (visual episodic memory) | 2012-2016 | |
Primary | Neuropsychological measure 4 | Hopkins Verbal Learning Test Revised (verbal episodic memory) | 2012-2016 | |
Primary | Neuropsychological measure 5 | CANTAB Simple and Choice Reaction Time (processing speed) | 2012-2016 | |
Primary | Neuropsychological measure 6 | WAIS-R Digit Symbol Test (processing speed) | 2012-2016 | |
Primary | Neuropsychological measure 7 | Trail Making Test A and B (processing speed/executive functioning) | 2012-2016 | |
Primary | Neuropsychological measure 8 | WAIS-R Digit Span forward and backwards (executive functioning) | 2012-2016 | |
Primary | Neuropsychological measure 9 | Graded Naming Test (semantic memory) | 2012-2016 | |
Primary | MRI Measures 1 | Siemens 3T - T1-weighted scan (MPRAGE) using FSL FIRST, FAST, and Freesurfer Volume extractions | 2012-2016 | |
Primary | MRI Measures 2 | Siemens 3T - T1-weighted scan (MPRAGE) using FSL GLM Voxel based analysis for grey matter density analysis | 2012-2016 | |
Primary | MRI Measures 3 | Siemens 3T - T2-weighted scan, clinical and FSL (BIANCA)-based rating of white matter changes | 2012-2016 | |
Primary | MRI Measures 4 | Siemens 3T Diffusion Tensor Images analyzed with Tract Based Spatial Statistics (TBSS) | 2012-2016 | |
Primary | MRI Measures 5 | Siemens 3T rs-fMRI analyzed with Multivariate Exploratory Linear Optimized Decomposition into Independent Components: MELODIC) | 2012-2016 |
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