Dementia Clinical Trial
Official title:
Exercise & Health Promotion for MCI: A Controlled Trial
The purpose of this project is to evaluate an exercise and health promotion program for older adults with mild memory loss. The study will investigate the efficacy of a memory-enhanced exercise and health promotion program to determine whether it is more effective than a social walking program in delaying further memory decline, improving mood and physical function, and enhancing quality of life.
This project is a randomized controlled trial to evaluate the efficacy of a group exercise
and health promotion program designed specifically for older adults with Mild Cognitive
Impairment (MCI). This study builds upon previous studies designed for cognitively intact
older adults, with a supplemental study using a modified intervention for MCI participants,
and for individuals with Alzheimer's disease.
Taken together, these prior investigations support the efficacy of behaviorally based
exercise interventions in improving cognitive, physical, and affective status in cognitively
intact and demented older adults. Results from a feasibility study suggest that these
positive outcomes can also be obtained in older adults with MCI.
The current study will investigate the efficacy of the modified exercise program called
RALLI (Resources and Activities for Life Long Independence) to determine whether it is more
effective than the control condition, a social walking program (SW), in delaying cognitive
decline, improving self-rated health and health behaviors, improving affect and physical
function, and enhancing quality of life. The long-term efficacy of RALLI to delay conversion
of MCI to dementia, reduce physical disability, maintain independent living, and improve
physiological health indicators will also be investigated.
One hundred seventy participants over the age of 70 who meet American Academy of Neurology
criteria for MCI will be recruited from independent living retirement residences.
Participants will be randomly assigned to one of the two conditions (RALLI and SW) and
assessed at baseline, post treatment (3 months), and follow up visits every 6 months for a
total of 3 years (months 6, 12, 18, 24, 30, and 36). The hypothesis is that RALLI
participants will experience better post-treatment outcomes than SW participants, and that
gains will be maintained over 36 months.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05686486 -
Gentle Gymnastics and Relationship Between Family Caregivers and Residents With Dementia in Nursing Homes
|
N/A | |
Terminated |
NCT05451693 -
Outreach-ER: A Dementia Care Intervention Program
|
||
Recruiting |
NCT05820919 -
Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase
|
N/A | |
Enrolling by invitation |
NCT06040294 -
Dementia and Disability Simulation for College Nursing Students' Senior Activity Facilitation Skills
|
N/A | |
Completed |
NCT05114187 -
An Internet-Based Education Program for Care Partners of People Living With Dementia
|
N/A | |
Recruiting |
NCT06322121 -
Vascular Aspects in Dementia: Part 2
|
||
Active, not recruiting |
NCT03676881 -
Longitudinal Validation of a Computerized Cognitive Battery (Cognigram) in the Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease
|
||
Completed |
NCT04426838 -
Cognitive Behavioral Therapy for Insomnia for the Dementia Caregiving Dyad
|
N/A | |
Recruiting |
NCT03462485 -
Pilot Study of the Effects of Playing Golf on People With Dementia
|
N/A | |
Active, not recruiting |
NCT03677284 -
Managing Time With Dementia: Effects of Time Assistive Products in People With Dementia
|
N/A | |
Completed |
NCT03849937 -
Changing Talk Online (CHATO) Study
|
N/A | |
Recruiting |
NCT06284213 -
Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
|
||
Recruiting |
NCT05579236 -
Cortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer's Disease
|
||
Completed |
NCT05080777 -
Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems
|
N/A | |
Completed |
NCT04571697 -
A Study of Comparing Rates of Dementia and Alzheimer's Disease in Participants Initiating Methotrexate Versus Those Initiating Anti-tumor Necrosis Factor (TNF)-Alpha Therapy
|
||
Completed |
NCT03583879 -
Using Gait Robotics to Improve Symptoms of Parkinson's Disease
|
N/A | |
Recruiting |
NCT06033066 -
Financial Incentives and Recruitment to the APT Webstudy
|
N/A | |
Active, not recruiting |
NCT05204940 -
Longitudinal Observational Biomarker Study
|
||
Recruiting |
NCT05684783 -
Dementia Champions in Homecare
|
||
Completed |
NCT03147222 -
Function Focused Care: Fracture Care at Home
|
N/A |