Dementia With Lewy Bodies Clinical Trial
Official title:
Effects of Nucleus Basalis of Meynert Area Electrical Stimulation on Cognitive Behavioral Disorders in Dementia With Lewy Bodies : A Pilot Phase 1 Study
Deep brain stimulation has been developed as a substitute for the classical lesioning methods
previously used in stereotactic and functional neurosurgery. Recent, anecdotal cases reports
suggested that electrical stimulation of the cholinergic output of the Nucleus Basalis of
Meynert (NBM) may improve cognitive performances, especially the memory tasks.
The present study aims to assess the effect of bilateral electrical stimulation of the NBM on
the mnesic performance [assessed by the sum of the three free recalls of the Free and Cued
Selective Recall Reminding Test (FCSRT)] in patients diagnosed with probable, moderate,
Dementia with Lewy Bodies.
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