Dementia of the Alzheimer Type Clinical Trial
Official title:
Effect of the Stage Specific Cognitive Intervention Program on Functional Cortical Activation in Alzheimer's Disease
The study aims to detect the effect of a structured cognitive rehabilitation program, teh stage specific intervention STACog, on cognitive performance and functional activation in fMRI in a group of patients with mild cognitive impairment and dementia due to Alzheimer's disease compared to a waiting group control sample. Baseline performance in cognitive tests and fMRI will further be assessed compared to healthy control subjects.
Subject of the proposed project is to offer based on existing theoretical principles and
methods stage-related, reproducible, relevant to everyday life group training in German for
people with aMCI and slightly severe AD and compared with a - in terms of goal variables -
to be less effective prestigious intervention . It is believed that the "active treatment" -
in the intervention group, the overall level of functioning can longer be maintained and
that positive transfer effects on non-cognitive level - to achieve and cognitive level -
here at nationals. In addition, information is expected that the conversion rate of people
with dementia and aMCI cut to a further loss of independence in humans can be delayed
slightly with severe AD. The project aims to provide data to estimate the effect sizes of
intervention can be determined on the basis of group size and duration of ongoing
investigations.
Involving functional imaging measures, the intervention study, an adequate platform for the
detection of intervention effects on neurobiological basis using fMRI dar. Here, the
cerebral blood flow in specific activation as a measure of neuronal and synaptic activity
and integrity both in cross-section of a subsample of healthy elderly people studied
determined and changes in cerebral activity patterns in people with severe AD, aMCI or
slightly in comparison pre-/post interventions. There are detectable much earlier in the
pathogenesis of functional changes as structural, using fMRI, the study is to make a
significant contribution to prove whether a modular cognitive intervention altered neural
and synaptic activity and whether this change is accompanied by an improvement in cognitive
performance.
A complete and proven effectiveness of cognitive group training could make a significant
contribution that people with MCI and severe AD easily submit their own initiative mental
condition, and add itself to sustain the intellectual, emotional and social potential. As a
long-term perspective, the results for the optimization of cognitive intervention programs
and continue to implement the organizations of the open and contribute stationary the
elderly and specialized medical facilities and other medical facilities.
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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