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WHO Covid 19 - Neurological Abnormalities in SARS-CoV-2 ICU Patients — NeuroCovid  

Delirium Clinical Trial

Official title:
Neurological Abnormalities in SARS-CoV-2 ICU Patients. A Prospective Study. NeuroCOVID Study

Clinical Trial Summary

The SARS-CoV-2 epidemic is leading to a large number of patients in intensive care units due to severe hypoxemic pneumonia. After an acute phase that may require controlled mechanical ventilation and deep sedation, removal of sedation often reveals a pathological awakening in the vast majority of patients. This encephalopathy state remains, to date and to our knowledge, unexplained. Clinical features do not appear to fully correlate with regular delirium. This encephalopathy might be explained by deep and prolonged hypoxemia, a wide use of sedation drugs, systemic inflammation or the hostile ICU environment.

Clinical Trial Description

This study is intended to investigate neurological abnormalities associated with SARS-CoV-2 infection. Complete daily neurological examinations will be routinely conducted in intensive care unit patients. Specific biological analyses will also be performed in these patients by collecting additional blood samples from an arterial or central catheter, every 2 days. These clinical and biological examinations will be continued throughout patient's stay in the intensive care unit. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04643548
Study type Observational
Source University Hospital, Clermont-Ferrand
Contact Lise Laclautre
Phone +33 4 754 963
Email llaclautre_perrier@chu-clermontferrand.fr
Status Recruiting
Phase
Start date October 13, 2020
Completion date August 13, 2021
View Details
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