Melatonin for Delirium Prophylaxis

Status Withdrawn

Clinical Trial Summary

Delirium is a common complication of illness especially among the elderly with serious sequelae including increased mortality, morbidity and length of stay. This neuropsychiatric emergency has key features including acute onset, fluctuating level of consciousness, poor attention and cognitive deficits with a presentation which may include hallucinations and delusions. A critical precipitating and maintaining feature of delirium is disrupted sleep. Melatonin is a widely available natural health product with evidence in normalizing circadian rhythms and sleep. There is also preliminary evidence that melatonin can be used to prevent the development of delirium in hospitalized patients. We hypothesize that daily administration of melatonin (1.5mg) in the evening, beginning at first admission to hospital and continuing for 14 days, will lead to decreased rates of delirium compared to placebo-treated comparison subjects.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Delirium

Clinical Trial Details

NCT number	NCT02282241
Study type	Interventional
Source	University of British Columbia
Contact
Status	Withdrawn
Phase	Phase 4
Start date	February 2016
Completion date	September 2021

View Details

See also
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