The Preventive Effects of Neurodynamic Mobilisation

Status Completed

Clinical Trial Summary

The aim of this study was to investigate the effects of neurodynamic mobilization (NM) technique on muscle damage and inflammation biomarkers, and pain, pressure pain threshold, range of motion (ROM), muscle strength, and functional status in delayed onset muscle soreness (DOMS). In the study, 32 healthy sedentary male volunteers were randomly divided into two groups as NM (n = 16) and placebo-NM (n = 16). After the initial evaluation of the individuals, femoral nerve NM and placebo NM techniques were administered three sets a day with ten repetitions for three days a week for three weeks. Three days after the end of the applications, the second evaluations were made and the DOMS creation protocol for the quadriceps femoris (QF) muscle was initiated. In order to trigger DOMS in individuals, 30 sets and 10 repetitions of eccentric knee extension (35°-95° flexion angles, 30°/sec speed) were performed on the dominant lower extremity with an isokinetic dynamometer. Baseline evaluations were repeated immediately after the DOMS protocol, and at hours 24, 48, and 72. During evaluations, muscle damage (serum creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin, aspartate aminotransferase (AST), and alanine aminotransferase) and inflammation (interleukin-6 (IL-6), interleukin-10, interleukin-1 beta, tumor necrosis factor-alpha, and C reactive protein) biomarkers, pain (activity), pressure pain threshold, ROM, muscle strength (QF, hamstring eccentric/concentric) and performance (one-leg jump, vertical jump) parameters were measured.

Clinical Trial Description

The aim of this study was to investigate the effects of neurodynamic mobilization (NM) technique on muscle damage and inflammation biomarkers, and pain, pressure pain threshold, range of motion (ROM), muscle strength, and functional status in delayed onset muscle soreness (DOMS). In the study, 32 healthy sedentary male volunteers were randomly divided into two groups as NM (n = 16) and placebo-NM (n = 16). After the initial evaluation of the individuals, femoral nerve NM and placebo NM techniques were administered three sets a day with ten repetitions for three days a week for three weeks. Three days after the end of the applications, the second evaluations were made and the DOMS creation protocol for the quadriceps femoris (QF) muscle was initiated. In order to trigger DOMS in individuals, 30 sets and 10 repetitions of eccentric knee extension (35°-95° flexion angles, 30°/sec speed) were performed on the dominant lower extremity with an isokinetic dynamometer. Baseline evaluations were repeated immediately after the DOMS protocol, and at hours 24, 48, and 72. During evaluations, muscle damage (serum creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin, aspartate aminotransferase (AST), and alanine aminotransferase) and inflammation (interleukin-6 (IL-6), interleukin-10, interleukin-1 beta, tumor necrosis factor-alpha, biomarkers, pain (activity), pressure pain threshold, ROM, muscle strength (QF, hamstring eccentric/concentric) and performance (one-leg jump, vertical jump) parameters were measured. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05326893
Study type	Interventional
Source	Gazi University
Contact
Status	Completed
Phase	N/A
Start date	February 20, 2020
Completion date	May 10, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02602353` - Pilot Study Comparing the Efficacy and Safety of a New Pain Patch and Placebo in Delayed Onset Muscle Soreness (DOMS)	Phase 2
Completed	`NCT02339129` - Dosing Interval Study of SST-0225 Topical Ibuprofen Cream in the Treatment of Delayed Onset Muscle Soreness	Phase 2
Completed	`NCT03876080` - Dry Needling in Subjects With Delayed Onset Muscle Soreness	N/A
Completed	`NCT02087748` - An Investigator Initiated, Within-Subject, Proof of Concept Study to Assess the Efficacy and Safety of Voltaren Gel in Subjects With DOMS	Phase 4
Recruiting	`NCT03619928` - Comparison of Dry Needle and Massotherapy on Tolerance Effort and Soreness	N/A
Recruiting	`NCT04128670` - Effects of Kinesio Tape on Delayed Onset Muscle Soreness	N/A
Completed	`NCT02322489` - Efficacy of Microcurrent Therapy After Eccentric Exercise	N/A
Completed	`NCT02324985` - Phase II Study of AP0302 5% Versus a Vehicle Comparator	Phase 2
Completed	`NCT04012203` - Multivariable Recovery After Exercise-induced Muscle Pain in the Forearm Muscles
Completed	`NCT02113566` - A Study Comparing the Efficacy and Safety of Orally Administered Ibuprofen and Placebo in Delayed Onset Muscle Soreness	Phase 4
Completed	`NCT02018211` - Neuromuscular Electrical Stimulation Via the Peroneal Nerve Reduces Muscle Soreness Following Intermittent Exercise	N/A
Completed	`NCT04755608` - The Effect of Low-Intensity Resistance Exercise Training	N/A
Completed	`NCT05026944` - Effects of Percussive Massage Treatment With Theragun on Post Exercise Delayed Onset Muscle Soreness	N/A
Active, not recruiting	`NCT06076356` - Effects of Foam Roller Versus KT Tape on Delayed Onset Muscle Soreness	N/A
Completed	`NCT02157675` - Effects of a Polyherbal Supplement on the Signs and Symptoms of Delayed Onset Muscle Soreness	Phase 4

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.