Rehydration Efficiency During Ad-libitum Fluid Intake

Dehydration Clinical Trial

— LIV-D2O  

Official title:

Rehydration Efficiency During Ad-libitum Fluid Intake

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06414291
• Other study ID #: FP00039672
• Status: Not yet recruiting
• Phase: N/A
• Start date: May 21, 2024
• Est. completion date: May 31, 2025

Study information

• Verified date: May 2024
• Source: Arizona State University
• Contact: Stavros Kavouras, PhD
• Phone: (602) 496-2547
• Email: stavros.kavouras[@]asu.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

It is well established that rehydration with a carbohydrate-electrolyte solution is more effective in comparison to plain water. This is primarily based on the sodium-glucose co transporter, based on which the world health organization has based its oral rehydration solution recommendations. Also, rehydration with a solution that includes sodium and glucose plasma osmolality should not drop as much as it happens during rehydration with water. As a result, we should have higher fluid intake due to higher thirst perception and lower urinary output due to higher levels of vasopressin.

The present study aims to examine the effectiveness of a electrolyte-glucose drink on rehydration following exercise-induced dehydration.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 20
• Est. completion date: May 31, 2025
• Est. primary completion date: December 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Age 18-60 years

• Training at least 2 times per week

• stable weight for the last 2 months (fluctuation less than 5 pounds)

Exclusion Criteria:

• Night shifting work

• Thyroid medication

• Bariatric surgery

• Cardiovascular disease

• Renal disease

• Hepatic disease

• Participating in another study at the same time

• Bodyweight over 110 pounds

Related Conditions & MeSH terms

• Dehydration

Intervention

Other:
• Plain Water
Plain water without calories, sweetener, or electolytes
• Liquid IV Hydration Multiplier
Drink with 22 grams of carbohydrate, 1020 milligrams of sodium, and 760 milligrams of potassium per liter. Hydration multiplier liquid IV
• Liquid IV Sugar Free
10 grams of carbohydrate, 1060 milligrams of sodium, and 760 milligrams of potassium per liter. Sugar free Liquid IV

Locations

Country	Name	City	State
United States	Interdisciplinary Science and Technology Building 8	Phoenix	Arizona

Sponsors (1)

Lead Sponsor	Collaborator
Arizona State University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Total fluid intake	Total amount of fluid ingested	4 hours of rehydration
Primary	Net fluid balance	amount of water retained during the rehydration period	at 4 hours of the rehydration period
Primary	Net fluid balance	amount of water retained during the rehydration period	at 3 hours of the rehydration period
Primary	Rate of absorption	The rate of Deuterium appearance in the blood during 30 minutes of rehydration	during the first 30 minutes of rehydration
Primary	Rate of absorption	The rate of Deuterium appearance in the blood during 60 minutes of rehydration	during the first 60 minutes of rehydration
Primary	Rate of absorption	The rate of Deuterium appearance in the blood during 120 minutes of rehydration	during the first 120 minutes of rehydration
Primary	Rate of absorption	The rate of Deuterium appearance in the blood during 180 minutes of rehydration	during the first 180 minutes of rehydration
Primary	Rate of absorption	The rate of Deuterium appearance in the blood during 240 minutes of rehydration	during the first 240 minutes of rehydration
Primary	Cumulative urine output	Total amount of urine output during rehydration	during the first 3 hours of rehydration
Primary	Cumulative urine output	Total amount of urine output during rehydration	during the first 4 hours of rehydration
Secondary	Plasma copeptin	Plasam Copeptin during rehydration	at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Secondary	Plasma volume	percent of plasma volume recovery during the rehydration	at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Secondary	Free water Clearance	Free water clearance calculated based on plasma and urine osmolality	at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Secondary	Free Osmotic Clearance	Free Osmotic clearance calculated based on plasma and urine osmolality	at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Secondary	Thirst	Thirst estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception	at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Secondary	Stomach fullness	Stomach fullness estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception	at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period
Secondary	Taste Likeness	Taste Likeness estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception	at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period