Dehydration Clinical Trial
Official title:
Hydration Dynamics and Influence of Beverage Composition
Verified date | July 2023 |
Source | University of Illinois at Chicago |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The study examines interactions between fluid availability in the gut and fluid retention in the body. The relative rate of fluid uptake, the expansion of the plasma volume, and percent of fluid retained by the body will be measured in response to ingestion of beverages of different composition. Healthy, euhydrated adults will be studied. The results will help establish formulations of beverages that sustain if not promote acute euhydration.
Status | Completed |
Enrollment | 14 |
Est. completion date | November 30, 2022 |
Est. primary completion date | October 31, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 45 Years |
Eligibility | Inclusion Criteria: - Have a BMI of 18.5 to 29.9 kg/m2. - Be normotensive (<120/80 mm Hg). - Must be able to speak and read English. - Be physically active or a regular exerciser but be able to abstain from exercise for 48 h prior to each study trial. - Fast for at least 8 hours prior to and through the study trial. - Be able to abstain from alcohol for 48 h prior to each study. - Be able to abstain from caffeine for 24 h prior to each study. - If female, must have regular menstrual cycles, that are > 27 days and < 35 days in length. Exclusion Criteria: - Under 18 y of age or over 45 y of age. - Have a BMI <18.5 or >30. - Being pregnant. - Lactating. - Tobacco user. - Have hypotension or hypertension. - Have any type of kidney disease or dysfunction. - Have diabetes. - Have any type of cardiovascular disease. - Have been diagnosed with galactosemia. - Females with irregular menstrual cycles. - Females with polycystic ovary disease. |
Country | Name | City | State |
---|---|---|---|
United States | University of Illinois Chicago | Chicago | Illinois |
Lead Sponsor | Collaborator |
---|---|
University of Illinois at Chicago |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Rate of appearance of deuterium in the plasma for placebo | Measure the rate of fluid uptake by the gut using appearance of deuterium oxide, or D2O, in the blood after ingesting a fixed volume of placebo. | 2 hours | |
Primary | Rate of appearance of deuterium in the plasma for oral rehydration solution 1. | Measure the rate of fluid uptake by the gut using appearance of deuterium oxide, or D2O, in the blood after ingesting a fixed volume of placebo. | 2 hours | |
Primary | Rate of appearance of deuterium in the plasma for oral rehydration solution 2. | Measure the rate of fluid uptake by the gut using appearance of deuterium oxide, or D2O, in the blood after ingesting a fixed volume of placebo. | 2 hours | |
Secondary | Fluid retention for placebo | Measure fluid retention using the difference between ingested volume and cumulative urine excretion as a percentage of the ingested volume. | 2 hours | |
Secondary | Fluid retention for oral rehydration solution 1 | Measure fluid retention using the difference between ingested volume and cumulative urine excretion as a percentage of the ingested volume. | 2 hours | |
Secondary | Fluid retention for oral rehydration solution 2 | Measure fluid retention using the difference between ingested volume and cumulative urine excretion as a percentage of the ingested volume. | 2 hours | |
Secondary | Change in plasma volume for placebo | Increase in plasma volume (water content of the blood) following ingestion of beverage | 2 hours | |
Secondary | Change in plasma volume for oral rehydration solution 1 | Increase in plasma volume (water content of the blood) following ingestion of beverage | 2 hours | |
Secondary | Change in plasma volume for oral rehydration solution 2 | Increase in plasma volume (water content of the blood) following ingestion of beverage | 2 hours |
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