Dehydration (Physiology) Clinical Trial
Official title:
Dehydration and Population Health
Verified date | August 2020 |
Source | Wayne State University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The primary aim of this study is to assess cardiovascular changes (blood pressure, heart rate, electrocardiogram/ECG) in response to mild fluid-restriction dehydration and subsequent rehydration in healthy young and old people. Secondary aims are to assess changes in body composition, mood, and hunger in response to mild dehydration and rehydration.
Status | Active, not recruiting |
Enrollment | 40 |
Est. completion date | November 6, 2022 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility |
Inclusion Criteria: - Healthy (no regular prescription medication usage) - Able to walk continuously on treadmill for 60 minutes Exclusion Criteria: - Confirmed or suspected pregnancy - Chronic medical condition - Regular prescription medication use - Inability to walk continuously walk on a treadmill for 60 minutes |
Country | Name | City | State |
---|---|---|---|
United States | #055 Education Building, Wayne State University | Detroit | Michigan |
Lead Sponsor | Collaborator |
---|---|
Wayne State University | University of Chicago |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cardiovascular changes | Changes in QRS waveforms will be assessed using electrocardiograms (ECG) before and after dehydration (fluid restriction) | change from baseline to dehydration (+13 hours) and then rehydration (+15 hours) | |
Secondary | Changes in perception of thirst and hunger | Thirst and hunger will be assessed on a VAS (visual analogue scale) before and after dehydration (fluid restriction) | change from baseline to dehydration (+13 hours) and then rehydration (+15 hours) | |
Secondary | Changes in body composition | Body composition (bone, lean, and fat mass) will be assessed using dual energy x-ray absorptiometry (DXA) scans before and after dehydration (fluid restriction) | change from baseline to dehydration (+13 hours) and then rehydration (+15 hours) | |
Secondary | Changes in mood | Mood will be assessed using the POMS (profile of mood states) survey before and after dehydration (fluid restriction) | change from baseline to dehydration (+13 hours) and then rehydration (+15 hours) |
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