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Pharmacokinetic Analysis of Midazolam and Fentanyl in Pediatric Patients With Long-term Analgosedation — Morpheus  

Deep Sedation Clinical Trial

Official title:
Pharmacokinetic Analysis of Midazolam and Fentanyl in Pediatric Patients With Long-term Analgosedation.

Clinical Trial Summary

Pharmacokinetic monitoring of midazolam, it's active metabolite and fentanyl in pediatric patients with long-term analgosedation will be performed. Especially, the chronologic sequence of the quantified plasma levels during sedation and during wake-up as well as the correlation to dose and sedation depth will be focused.

Clinical Trial Description

At pre-defined timepoints (see below) serum Levels of the above mentioned drugs and metabolites will be determined and pharmakokinetic (PK) modeling will be performed. PK data will be correlated to sedation depth, as assessed using a validated score. Three Age Groups (infants, children and adolescents) will be evaluated considering the physiologic properties during pediatric development. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02302391
Study type Observational
Source Universitätsklinikum Hamburg-Eppendorf
Contact
Status Completed
Phase
Start date October 2014
Completion date October 2018
View Details
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