Decreased Vascular Flow Clinical Trial
Constant despite changes in perfusion pressure. It is observed in many vascular beds of the
human body to prevent that variations in perfusion pressure are directly transmitted into
changes in blood flow. This is necessary to prevent ischemia and/or hypoxia during decreased
blood flow and bleeding or increased capillary pressure during increased blood flow.
In the eye, several studies have reported that retinal blood flow is autoregulated over a
wide range of ocular perfusion pressures. Unfortunately only few data are available for the
optic nerve head. To gain data about autoregulation is of special importance given that
several important ocular diseases such as glaucoma and age-related macular degeneration are
associated with impaired autoregulation. In humans most data were collected using laser
Doppler flowmetry.
The present study aims to investigate the phenomenon of transient reduction in blood flow
and to gain insight in the regulatory mechanisms of optic nerve head blood flow during
isometric exercise.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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