Single Dose Study of Phentolamine Mesylate Eye Drops in Patients With Severe Night Vision Disturbances — SNV  

Decrease in Night Vision Clinical Trial

Official title: Single Dose Study of Phentolamine Mesylate Eye Drops in Patients With Severe Night Vision Disturbances

Status Completed

Clinical Trial Summary

The objectives of this study are:

• To assess the effect of ophthalmic phentolamine mesylate in mesopic conditions on the four endpoints:

1. Contrast sensitivity

2. Low contrast visual acuity

3. Wavefront aberrometry

4. Subjective questionnaire

• To assess the safety of ophthalmic phentolamine mesylate

Clinical Trial Description

Double-masked, placebo-controlled, single-dose Phase 2 study in 24 patients experiencing severe night vision difficulties to evaluate ocular and systemic safety and efficacy following administration of one drop of phentolamine mesylate 1.0% QD in each eye for 1 day. ;

Related Conditions & MeSH terms

• Decrease in Night Vision
• Disturbance; Vision, Loss

• NCT number: NCT04004507
• Study type: Interventional
• Source: Ocuphire Pharma, Inc.
• Status: Completed
• Phase: Phase 2
• Start date: August 2007
• Completion date: February 2008