Decompression Sickness Clinical Trial
— DACODECOfficial title:
Decreases in Diffusing Lung Capacity for Carbon Monoxide (DLCO) in Occupational Divers and Their Impact on Decompression Sickness Risks
Verified date | June 2017 |
Source | University Hospital, Brest |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Diving disorders and particularly Decompression sickness (DCS) represent a major concern in recreational and occupational pressure-related activities. As a result of decompression from higher to lower ambient pressure bubbles which are formed in vascular flow and in tissues take part in embolism then resulting in DCS. Individual factors such as vascular or respiratory defects are now considered to increase the risk of this dysbarism disease.
Status | Completed |
Enrollment | 16 |
Est. completion date | May 30, 2017 |
Est. primary completion date | May 30, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Be professional and voluntary diver - Man or woman aged 18 years or older - Diffusing Lung Capacity for Carbon Monoxide measured beforehand in the study - No medical contraindication for hyperbaric - No hyperbaric constraint in 3 days before the dive - No prior Decompression sickness - Not to follow medicinal treatment modifying the vascular endothelial and/or the coagulation and/or the respiratory function - Patient affiliated to social security - Informed and signed Exclusion Criteria: - Concomitant pathology identified by the Investigator, justifying a contraindication for hyperbaric - Pregnant and nursing mothers - Patient who refuse to sign consent form |
Country | Name | City | State |
---|---|---|---|
France | Brest, University Hospital | Brest |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Brest |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Venous bubbles will be detected by precordial Doppler | Venous bubbles will be detected by precordial Doppler | 30 minutes after the dive | |
Secondary | Vascular abnormality | Assessement of microvascular reactivity by brachial artery flow mediated dilation | 60 minutes after the dive | |
Secondary | Coagulation activation | Assessment of blood coagulation factor after the dive | 60 minutes after the dive | |
Secondary | Inflammatory activation | Assessment of inflammatory factor after the dive | 60 minutes after the dive |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02118207 -
Exercise and Repetitive Diving
|
N/A | |
Completed |
NCT02468752 -
Reduction of Venous Emboli Load After Breathing Normobaric Oxygen Compared to Air
|
Phase 2/Phase 3 | |
Completed |
NCT02432131 -
Decompression Sickness in Divers With or Without Patent Foramen Ovale
|
||
Recruiting |
NCT03192956 -
Markers of Central Nervous System Injury in Decompression Sickness
|
||
Recruiting |
NCT04791488 -
Impact of Hyperoxia and Involvement of the Immune System in Diving Accident
|
N/A | |
Not yet recruiting |
NCT06370897 -
Prediction & Mechanisms of Recovery Following IEDS
|
||
Not yet recruiting |
NCT06216366 -
Rhu-pGSN to Mitigate Proinflammatory Responses to Decompression in Healthy SCUBA Divers
|
Phase 2 | |
Enrolling by invitation |
NCT02483650 -
Hyperbaric Oxygen Therapy Registry
|
||
Completed |
NCT02064361 -
High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation
|
N/A | |
Completed |
NCT03390335 -
Decompression Tables for Diving at Altitude
|
N/A | |
Completed |
NCT01587209 -
Microparticles in Scuba Divers With Decompression Sickness
|
N/A |