Cystitis, Interstitial Clinical Trial
Official title:
A Case Control Study of Interstitial Cystitis
EPIC is a case/control study that seeks to identify the risk factors for interstitial cystitis by comparing the experiences and medical histories of 400 women who recently developed IC with 400 similar people who do not have the disease.
This project is a systematic, national study of incident IC cases and controls matched by
age and gender. By telephone interview and medical record review, we compare exposures of
cases and controls seeking significant differences which may be risk factors for IC. This
cohort of incident IC cases will initiate a natural history study of the disease.
Specific Aim 1. To test the hypothesis that certain features that precede onset of IC
symptoms, e.g., bacterial cystitis, distinguish IC cases from controls matched for age and
gender, and may be risk factors for the disease.
Specific Aim 2. To test the hypotheses that patients with IC have higher prevalences of
certain non bladder syndromes, e.g., irritable bowel syndrome, than do controls matched for
age and gender.
Specific Aim 3. To test the hypothesis that urine APF, HB EGF, and/or EGF are sensitive and
specific diagnostic markers for IC in patients with symptoms of ÿ12 months.
Specific Aim 4. To test the hypotheses that, in an incident cohort, patients with IC have
remissions and that certain clinical features, e.g., bacterial cystitis at disease onset,
are prognostic factors for remissions.
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N/A
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