| Eligibility |
Inclusion Criteria:
1. Histologically confirmed CTCL as per Olsen et al, 2011 or per algorithm for diagnosis
of early MF as per Pimpinelli et al, 2005.
2. Patient-participants with Stage IA-IIB CTCL (MF) with injectable lesions (patches,
plaques, or tumors), who have relapsed or refractory disease following at least 1
prior standard treatment. Patient-participants who are unsuitable to receive standard
treatment or who have declined standard treatment are also eligible.
3. Patient-participants must have = 1 treatable/measurable lesion(s) for injection as per
Olsen criteria.
4. Understands and is able to comply with the study requirements and has signed the
informed consent form.
5. Has an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.
6. Life expectancy of at least 6 months.
7. Age 18 years or older at the time of signing the informed consent form.
8. Acceptable liver function:
1. Bilirubin equal 1.5x ULN.
2. AST (SGOT), ALT (SGPT) equal 3.0x ULN.
9. Acceptable renal function:
a. Serum creatinine = 1.5x ULN.
10. Acceptable hematologic status:
1. Absolute neutrophil count - 1500 cells/mm3
2. Platelet count - 100,000 /mm3
3. Hemoglobin - 9 g/dL.
11. Acceptable coagulation status: international normalized ratio = 1.5 ULN.
Patient-participants on therapeutic doses of vitamin K antagonists (eg, warfarin) or
direct oral anticoagulants (eg, direct thrombin or direct factor Xa inhibitors) are
not eligible.
Anticoagulation with low molecular weight heparins is permitted.
12. Women of child-producing potential agree to use highly effective contraceptive methods
(see Appendix C for details) for one complete menstrual cycle (or at least 30 days)
prior to the first dose of CDK-003 until 6 months following the last dose of CDK-003,
and avoid egg donation from the time of the first dose of CDK-003 until 6 months
following the last dose of CDK-003. A female participant is considered to be of
child-producing potential unless she:
1. has had a hysterectomy or bilateral oophorectomy or
2. is age = 60 years and is amenorrhoeic or
3. is age < 60 years and has been amenorrhoeic for = 12 months (including no
irregular menses or spotting) in the absence of any medication which induces a
menopausal state and has documented ovarian failure by serum estradiol and
follicle-stimulating hormone levels within the institutional laboratory
postmenopausal range).
13. A negative pregnancy test (if a woman of child-producing potential) within 72 hours
prior to the first dose of CDK-003.
14. Men of child-producing potential agree to use highly effective contraceptive methods
and avoid sperm donation from the time of the first dose of CDK-003 until 6 months
following the last dose. Male patient-participants must use a condom when engaged in
intercourse during the study and for 6 months after the last dose of study drug.
A man is considered to be of child-producing potential unless he has had a bilateral
vasectomy with documented aspermia or a bilateral orchiectomy.
15. Patient-participant agrees to have a pre-treatment tumor biopsy during the Screening
Period, and 2 on-treatment tumor biopsies of the same lesion.
Exclusion Criteria:
1. Patient-participants with CTCL disease involving N3 nodes.
2. Clinically significant ongoing AEs that have not returned to baseline or to Grade 1
National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE)
v5.0 during the Screening Period.
3. Received nitrogen mustard, PUVA, narrow band UVB light therapy, carmustine (BCNU),
other systemic therapies, radiation therapy or investigational agents for CTCL within
21 days of Day 1.
4. Received systemic corticosteroids within 28 days of Day 1.
5. Use of topical corticosteroids on any of the target lesions for CDK-003 injection or
non-injected target lesion within 28 days of Day 1. Topical corticosteroid use is
permitted for non-target lesions.
6. Major surgery within 2 months or minor surgery (excluding tumor biopsies) within 14
day prior to Day 1.
7. Clinically significant cardiovascular disease including but not limited to myocardial
infarction or stroke within the past 6 months prior to Day 1, New York Heart
Association Class III or IV heart failure, uncontrolled arrhythmia, or severe aortic
stenosis. Sponsor approval of patient-participants with an arrhythmia is required.
8. Active, uncontrolled bacterial, viral, or fungal infections requiring systemic
therapy.
Prophylactic antibiotics are acceptable.
9. Prior organ or stem cell transplant.
10. Primary immune deficiency.
11. Pregnant or nursing women.
12. Positive test for HBsAg, HCV Ab, or HIV Ab during the Screening Period.
13. Unwillingness or inability to comply with procedures required in this protocol.
14. Serious non-malignant disease (e.g., liver failure, ongoing infection requiring
intravenous treatment, psychological illness, autoimmune disease including but not
limited to inflammatory bowel disease, or other conditions) or social situations that,
in the opinion of the Investigator and/or the Sponsor, could compromise protocol
objectives or patient participant safety or the ability of the patient-participant to
comply with the protocol.
15. History of another malignancy, unless potentially curative treatment has been
performed. Sponsor approval is required. Patient-participants with early stage
prostate cancer on active surveillance may be enrolled with Sponsor approval.
16. Currently receiving any other anti-cancer or investigational agent.
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