Cryptogenic Epilepsy Clinical Trial
— POCS-DTIOfficial title:
Diffusion Tensor Imaging of the Thalamo-cortical Network in Epilepsy With Continuous Spikes and Waves During Sleep
Continuous Spikes and Waves during Sleep (CSWS) is a rare paediatric epileptic
encephalopathy. Even if the correlation between the severity of the epilepsy and the
cognitive consequences is well established, the mechanisms involved in epileptic cognitive
degradation are complex and poorly understood. In CSWS, there are many arguments for the
implication of cortical and subcortical cerebral structures. Among them the thalamus seems
to play a crucial role. In fact it is strongly implicated in the sleep and this function is
determining for learning. Moreover, it is part of the propagation pathway of generalized
forms of epilepsy like absences in animal studies. Unfortunately there is no animal model
for CSWS to confirm this theory. In human studies, few cases are caused by thalamic injuries
but most of the time conventional MRI is normal. Despite few literature on CSWS, some
studies reported abnormal functional connectivity especially in the thalamus.
The investigators hypothesize that the first utilisation of diffusion tensor imaging (DTI)
and tractography will be useful in CSWS to confirm the implication of a
cortico-thalamo-cortical network showing an abnormal structural connectivity. The
investigators will try to determinate if a particular thalamic nucleus is concerned and
demonstrate a link between the disease severity (duration and cognitive consequences) and
the importance of structural abnormalities.
Using resting state functional MRI (fMRI), the investigators will also try to investigate
the default mode network. Its implication was also suggested in the literature.
| Status | Recruiting |
| Enrollment | 45 |
| Est. completion date | February 2020 |
| Est. primary completion date | February 2020 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 5 Years to 40 Years |
| Eligibility |
Inclusion Criteria: - - for the patients, diagnosis of CSWS according to the current diagnostic criteria (ILAE 2001) - minimal age of 5 years old - written consent to participate in the study from the subjects who could write and/or from the parents or legal representative Exclusion Criteria: - rejection of the patient or its legal representative - no respect of inclusion criteria |
| Country | Name | City | State |
|---|---|---|---|
| France | CHU Clermont-Ferrand | Clermont-ferrand |
| Lead Sponsor | Collaborator |
|---|---|
| University Hospital, Clermont-Ferrand |
France,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Structural connectivity of the thalamo-cortical network | Structural connectivity of the thalamo-cortical network will be assessed using DTI fractional anisotropy. The data of CSWS patients will be statistically compared to healthy volunteers |
at day 1 | |
| Secondary | Some comparisons with electrophysiological and neuropsychological data will be done | at day 1 |