Corticosteroids With Vedolizumab in Crohn's Disease

Status Terminated

Clinical Trial Summary

Use of co-induction with corticosteroid therapies may accelerate the remission rate when used with vedolizumab. Further, this may lead to higher rates of response and remission at week 10 than would be seen with vedolizumab monotherapy.

Clinical Trial Description

This study will examine prednisone co-induction with vedolizumab in patients with Crohn's disease. To address questions regarding the effect of co-induction on mucosal healing, the study will include colonoscopic assessment of mucosal healing. Finally, colonic biopsies in this study will allow to elucidate further the mechanism of action of vedolizumab in Crohn's disease through immune phenotyping studies. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02324699
Study type	Interventional
Source	Icahn School of Medicine at Mount Sinai
Contact
Status	Terminated
Phase	Phase 4
Start date	April 2016
Completion date	February 8, 2018

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