Crohn's Disease Clinical Trial
Official title:
A Randomized, Controlled Study of Soluble Dietary Fiber on Bacterial Translocation in Adults Patients With Crohn's Disease
The purpose of this study is to evaluate the effect of soluble dietary fiber on bacterial translocation and mucosal immunology in patients with Crohn's disease.
Bacterial translocation (BT) is a proposed mechanism of CD. Microorganisms can be cultured
from 18-48% of draining mesenteric lymph nodes from CD patients. A breakdown in barrier
function in "late stage" CD has been observed in patients requiring surgery. In addition, it
was found that BT influences the response to biological therapy and clinical relapse in CD.
Therefore, reducing BT may be of therapeutic importance in treatment for CD.
The role of soluble dietary fiber in Crohn's disease (CD) is still inconclusive. Population
based studies have shown that long-term intake of dietary fiber is associated with lower risk
of CD. However, meta-analysis did not show benefit in inducing or maintaining remission. In
addition, the possible mechanism of dietary fiber on CD is still unclear.
The rationale relates to the beneficial effects of fiber may be due to the production of the
fiber metabolites short-chain fatty acids (SCFAs), particularly butyrate. Dietary substrates
may modify the commensal microbiota or their metabolites or enhance epithelial barrier
function. Recently, it was found that dietary fiber metabolites SCFA is regulatory of mucosal
regulatory T cells. The current study is to examine the impact of dietary fiber on bacterial
translocation,intestinal luminal microbiology, and mucosal immunology in CD patients.
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