Brain-Gut Interactions in Crohn's Disease

Status Completed

Clinical Trial Summary

The primary aims for this research are to 1) characterize brain changes in patients with CD compared to age and gender-matched controls and 2) relate these brain changes to measures of disease activity and pain severity.

Clinical Trial Description

Brain‐gut interactions have been studied in chronic pain conditions of the gastrointestinal (GI) tract such as irritable bowel syndrome (IBS) and chronic pancreatitis. These studies suggest that alterations in the brain‐gut axis may relate to disease severity and pain perception. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by periods of disease activity and periods of disease quiescence. Crohn's disease (CD) is one of the two major subtypes of IBD. Patients with CD typically experience abdominal pain when the disease is active; however, many also report experiencing pain in the absence of objective evidence of inflammation. Alterations in brain‐gut interactions may explain the perception of pain in these patients. Currently, there is a paucity of data regarding brain changes in patients with IBD and CD, specifically. We are proposing a pilot study to characterize brain‐gut interactions of disease activity and pain modulation mechanisms in patients with IBD using advanced neuroimaging tools. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02108938
Study type	Observational
Source	University of Wisconsin, Madison
Contact
Status	Completed
Phase
Start date	September 10, 2014
Completion date	May 18, 2015

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