Crohn's Disease Clinical Trial
Official title:
Value of Contrast-enhanced Ultrasonography and Magnetic Resonance Enterography to Predict the Efficacy of Anti-TNF Therapy in Crohn's Disease Complicated by Symptomatic Small Bowel Stricture
The value of anti-TNF therapy in intestinal strictures related to Crohn's disease (CD) has
not been clearly demonstrated. The results reported by some teams suggest no beneficial
effect or even an increased risk of bowel obstruction in the case of stricture, while other
publications indicate a favourable action of anti-TNF in this setting. The efficacy of
anti-TNF in patients with intestinal stricture related to Crohn's disease could depend on
the lesions responsible for the stricture, as anti-TNF agents are probably effective in
inflammatory forms and useless or even potentially harmful in fibrotic forms. In practice,
the decision is currently empirical and a trial of anti-TNF therapy is often proposed.
In view of the high incidence of intestinal strictures in CD and the need for a treatment as
effective as anti-TNF in this setting, it is important to more clearly define the
indications of these treatments guided by the information provided by modern imaging.
The aim of this prospective study is to determine whether certain signs detected by MR
enterography and contrast-enhanced ultrasonography can help to predict failure of anti-TNF
therapy in patients with CD presenting a symptomatic stricture of the small bowel and
scheduled to receive this treatment.
n/a
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