Crohn's Disease Clinical Trial
The purpose of this study is to characterize the skeletal deficits and risk factors for
impaired skeletal development in children requiring glucocorticoid therapy.
We will compare the bone health of children treated with prednisone for nephrotic syndrome
(NS with those treated with prednisone for Crohn's Disease (CD). Childhood NS usually
responds to prednisone and is not characterized by pathologies that can impact on bone. In
contrast, CD is treated with prednisone, but is independently associated with poor growth
and maturation, nutritional deficiencies and inflammation. Due to the differences in the
diseases, this comparison will allow us to distinguish between the prednisone-related and
disease-related effects on bone in the two disease states.
Prednisone, a glucocorticoid medication, is widely used for many pediatric disorders.
Studies have shown that this drug decreases bone formation, decreasing bone density and bone
thickness in children. Prednisone induced osteopenia, or low bone density, can be worsened
by the effects of the underlying disease, such as delayed growth and maturation,
malnutrition, and increased bone resorption (removal) by inflammatory compounds. The
combined effects of decreased bone formation and increased resorption may be particularly
detrimental to the growing skeleton.
Subjects will include 15 newly diagnosed NS patients, 60 patients with pre-existing NS, 90
patients with newly diagnosed CD, 45 patients diagnosed within the last two years and 200
healthy controls of similar age, gender and ethnicity. Participants will visit the
Children's Hospital of Philadelphia (CHOP) three times over a 12-month period for assessment
of bone mineralization and turnover, fracture history, dietary calcium intake, physical
activity, growth, body composition, muscle strength and glucocorticoid exposure.
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Time Perspective: Prospective
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