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Exclusion Diet vs corticosteroIds in patientS With activE Crohn's Disease — PARADISE  

Crohn Disease Clinical Trial

Official title:
Prospective rAndomized Controlled tRial of Crohn's diseAse Exclusion Diet vs corticosteroIds in patientS With activE Crohn's Disease - PARADISE

Clinical Trial Summary

Crohn's disease exclusion diet (CDED) is a whole-food diet coupled with partial enteral nutrition. The main objective of this trial is to assess whether CDED is superior to corticosteroids, in terms of endoscopic response, in patients active CD. The primary endpoint is endoscopic response at week 16, without corticosteroids or further therapeutic intervention, assessed by a centralized, anonymous and blinded, double lecture panel of panenteric PillCam Crohn's Capsule. This is a multicentre, open-label, comparative, randomized, 2:1, controlled, single-blind, superiority trial. Patients included are aged 16 to 70 years, have mild to moderate, luminal, active CD, and have active endoscopic lesions. Eighty patients will be randomized between CDED (n=56) and corticosteroids (n=24) in centres in France, Israel and the Netherlands.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05284136
Study type Interventional
Source Assistance Publique - Hôpitaux de Paris
Contact Franck Carbonnel, MD-PHD
Phone 142499742
Email fcarbonnel7@gmail.com
Status Not yet recruiting
Phase Phase 2/Phase 3
Start date April 1, 2022
Completion date April 1, 2026
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