Crohn Disease Clinical Trial
Official title:
Quantitative Analysis of Lipid Mediators in Colonic Biopsies From Patients With Inflammatory Bowel Diseases and From Control Patients.
We will quantify one of the lipid compounds (5,6 epoxy eicosatrienoic acid (5,6 EET), 5,6-
EpoxyEicosaTrienoic acid) in colonic biopsies of Inflammatory Bowel Disease patients. We
will evaluate its possible use as a pathological activity biomarker and its potential as a
therapeutic target.
We hypothesized that 5,6-EET is present in human colonic tissues in varying quantities
depending on the pathological state of the IBD patient.
The project is an exploratory physiopathological/translational pilot study, aiming at
understanding the relative importance of the lipid compounds, especially 5,6-EET, in
Inflammatory Bowel Diseases.
Using mass spectrometry, 5,6-EET and other 33 lipid metabolites will be quantified in situ
in colonic biopsies from IBD patients and from control patients. We will compare quantities
of 5,6-EET in inflammatory and non-inflammatory zones of biopsies from IBD patient to
biopsies from control patient. We will establish a cluster of lipid compounds associated
with pathological activity. We will determine the exposed profile of receptor lipid
mediators expressing to the 5,6-EET lipid compound and one of its signalization.
All data will be submit to statistical analysis to confirm relevance.
We expect this pilot study to help us define 5,6-EET and other components of the same
metabolic family as markers for IBD activity. It could point lipid mediators and their
receptors as potential new therapeutic targets.
It will increase our knowledge on current treatment efficiency by evidencing lipid markers
for the inflammatory condition.
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