Critically Ill Clinical Trial
Official title:
The Effect of Filter Lifespan in Continuous Renal Replacement Therapy on the Rate of New Infections in Critically Ill Patients: a Prospective, Multicenter, Observational Trial
The only supportive therapy for patients with AKI is renal replacement therapy (RRT). In the ICU setting, continuous RRT (CRRT) is mostly favored. In a post-hoc analysis of the RICH trial (regional citrate versus systemic heparin anticoagulation for CRRT in critically ill patient with AKI), it was shown that the filter life span is associated with an increased rate of new infection and that the type of anticoagulants did not directly affect infection rate. The mechanisms of this infection rate is unknown.
Approximately every second patient in the ICU suffers from acute kidney injury (AKI) which complicates the clinical course of these patients. Continuous renal replacement therapy (CRRT) has become the most widely used form of renal support in critically ill patients as it allows continuous, controlled removal of fluids and is hemodynamically better tolerated compared to intermittent dialysis. The requirement for intravascular access and artificial circuits may increase the risk of infection. However, there are no studies analyzing the incidence and characteristics of infections in critically ill patients with CRRT or the implications for outcome. Therefore, this observational trial investigates the factors that influences new onset infection in critically ill patients with CRRT. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05539521 -
Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation
|
Phase 2 | |
| Recruiting |
NCT04776486 -
Iohexol Clearance in Critically Ill Patients With Augmented Renal Creatinine Clearance
|
N/A | |
| Completed |
NCT05766319 -
The ICU-recover Box, Using Smart Technology for Monitoring Health Status After ICU Admission
|
N/A | |
| Recruiting |
NCT03231540 -
The PREServation of MUScle Function in Critically Ill Patients (PRESMUS)
|
N/A | |
| Completed |
NCT02286869 -
Cardioventilatory Coupling in Critically Ill Patients
|
N/A | |
| Completed |
NCT01434823 -
24 Hour Intensivist Coverage in the Medical Intensive Care Unit
|
N/A | |
| Active, not recruiting |
NCT01142570 -
Effect of Enteral Nutrition Enriched in Protein and Based on Indirect Calorimetry Measurement in Chronically Critically Ill Patients
|
N/A | |
| Completed |
NCT01167595 -
Enhanced Protein-Energy Provision Via the Enteral Route in Critically Ill Patients
|
N/A | |
| Completed |
NCT01293708 -
Realities, Expectations and Attitudes to Life Support Technologies in Intensive Care for Octogenarians:
|
||
| Not yet recruiting |
NCT00916591 -
Prokinetic Drugs and Enteral Nutrition
|
N/A | |
| Recruiting |
NCT00654797 -
Improving Blood Glucose Control With a Computerized Decision Support Tool: Phase 2
|
Phase 2 | |
| Withdrawn |
NCT00178321 -
Improving Sleep in the Pediatric Intensive Care Unit
|
N/A | |
| Completed |
NCT01168128 -
PERFormance Enhancement of the Canadian Nutrition Guidelines by a Tailored Implementation Strategy: The PERFECTIS Study
|
N/A | |
| Completed |
NCT02447692 -
Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study
|
N/A | |
| Recruiting |
NCT04582760 -
Early Mobilization in Ventilated sEpsis & Acute Respiratory Failure Study
|
N/A | |
| Not yet recruiting |
NCT05961631 -
Bio-electrical Impedance Analysis Derived Parameters for Evaluating Fluid Accumulation
|
||
| Completed |
NCT03276650 -
Admission of Adult-onset Still Disease Patients in the ICU
|
||
| Completed |
NCT03922113 -
Muscle Function After Intensive Care
|
||
| Recruiting |
NCT05055830 -
Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
|
||
| Recruiting |
NCT06027008 -
Mechanical Insufflation-Exsufflation (Cough Assist) in Critically Ill Adults
|
N/A |