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Impact of Gabapentin on Slow Wave Sleep in Adult Critically Ill Patient — GASWAC  

Critically Ill Clinical Trial

Official title:
Impact of Gabapentin on Slow Wave Sleep in Adult Critically Ill Patient.

Clinical Trial Summary

The investigators proposed that gabapentin will increase slow-wave sleep in adult critically ill patients. Increasing slow-wave sleep will improve the patients' outcomes (shortening ICU length of stay, improving ventilator free days, increasing delirium free days) in critically ill patients, a university hospital, Thailand.

Clinical Trial Description

Up to 61% of critically ill patients have sleep deprivation in ICU. Sleep deprivation can cause delirium and lead to prolonged ICU length of stay and mechanical ventilator days. However, pharmacologic interventions to improve sleep quality and prevent sleep deprivation are poorly tested for efficacy and safety in ICU patients. There were reports of gabapentin increasing slow-wave sleep in healthy populations and insomnia patients with insignificant adverse events. Therefore, gabapentin might increase slow-wave sleep resulting in improving clinical outcomes in adult critically ill patients. The objectives of the study were to evaluate the efficacy, especially on slow-wave sleep, and safety of gabapentin in adult critically ill patients admitted to ICUs at Ramathibodi Hospital, a university hospital, Thailand. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04818450
Study type Interventional
Source Mahidol University
Contact
Status Completed
Phase N/A
Start date April 19, 2021
Completion date July 31, 2022
View Details
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