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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05403489
Other study ID # HisarIH
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2021
Est. completion date May 31, 2022

Study information

Verified date June 2022
Source Hisar Intercontinental Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Introduction: Secondary pneumonia is frequently seen in COVID-19 cases followed up intubated, and high mortality rates can be observed. Isolation of the agent with bronchoalveolar lavage (BAL) culture or endotracheal aspirate (ETA) culture may increase the success of treatment. This study aimed to retrospectively analyze the results of BAL and ETA cultures in intubated COVID-19 cases. Methods: We routinely apply BAL culture with bronchoscopy or ETA culture within the first 48 hours after intubating. We retrospectively screened cases who underwent BAL and ETA. They were divided into two groups: Group B and E. Evaluated parameters were compared in both groups. Results: Demographic data and blood test results were similar in both groups. Intensive care unit (ICU) and intubation durations, and culture positivity were statistically significantly higher in Group B. Although not statistically significant, the mortality rate was higher in Group E. The most growth microorganisms were Candida species. Conclusion: Mortality rates were consistent with the literature. Since the microorganism isolation rate is higher with BAL and antimicrobial treatment is applied more effectively; early deaths were prevented and stay periods were prolonged. In contrast, these durations were shorter in the ETA group due to higher mortality. In intubated COVID-19 cases, a more effective treatment process can be carried out by clearing the airway with fiberoptic bronchoscopy and by specifically planning the treatment according to the BAL culture. This may have a positive effect on prognosis and mortality.


Recruitment information / eligibility

Status Completed
Enrollment 67
Est. completion date May 31, 2022
Est. primary completion date December 31, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Intubated COVID-19 patients - Above 18 years old patients Exclusion Criteria: - Non COVID-19 patients - Non intubated COVID-19 patients - Below 18 years old patients

Study Design


Intervention

Procedure:
Bronchoalveolar lavage
In cases approved for bronchoscopy, bronchoalveolar lavage was performed and culture analysis was performed.
endotracheal aspirate culture
In cases where consent for bronchoscopy could not be obtained, tracheal secretions were aspirated and culture analysis was performed.

Locations

Country Name City State
Turkey Hisar Intercontinental Hospital Istanbul

Sponsors (1)

Lead Sponsor Collaborator
Basri Cakiroglu

Country where clinical trial is conducted

Turkey, 

Outcome

Type Measure Description Time frame Safety issue
Primary Culture positivity Significantly higher microbiological culture growth rate was obtained in Group B 1 years
Primary Length of stay in intensive care unit Significantly higher duration of stay in intensive care unit was found in Group B 1 years
Primary Duration of intubation Significantly higher duration of stay intubated was observed in Group B 1 years
Primary Mortality Mortality rate was higher in Group E. But not statistically significant. 1 years
Secondary Microorganism The most growing microorganism in both groups was the Candida species. 1 years
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