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Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients — SAVE-O2  

Critical Illness Clinical Trial

Official title:
Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients (SAVE-O2)

Clinical Trial Summary

The objective is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in critically injured patients. Investigators will also evaluate the safety and clinical effectiveness of the more targeted use of oxygen therapy.

Clinical Trial Description

Oxygen therapy has undisputed importance in the care of critically ill patients to prevent secondary complications related to hypoxemia. Although routine, the practice of excessive over-oxygenation may be harmful. An expert panel was convened and developed the strong consensus to target normoxemia at an oxygen saturation (SpO2) range of 90-96%, an arterial oxygen (PaO2) range of 60-100 mmHg (when applicable), and a fraction of inspired oxygen (FiO2) of 21% for mechanically ventilated patients or room air for nonmechanically ventilated patients. Specific Aim: The purpose of this study is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in critically injured patients. Investigators will also evaluate the safety and clinical effectiveness of the more targeted use of oxygen therapy. Hypotheses: Clinical efforts to through a multimodal educational intervention will: 1. Improve the proportion of time spent within target normoxemia thresholds (oxygen saturation [SpO2] 90-96% and/or arterial oxygen [PaO2] 60-100 mmHg [when applicable] 2. Limit use of excessive supplemental oxygen 3. Reduce exposure to hyperoxemia without a substantive increase in hypoxemic episodes or adverse effects ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04534959
Study type Interventional
Source University of Colorado, Denver
Contact
Status Active, not recruiting
Phase Phase 3
Start date October 15, 2020
Completion date February 15, 2025
View Details
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