Use of suPAR Algorithm for the ED Decision Making

Critical Illness Clinical Trial

— EDsuPAR  

Official title:

Use of Algorithm for Safer and More Efficient Decision Making in the ED

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04402281
• Other study ID #: §33, HUS/141/2020 14.4.2020
• Status: Completed
• Start date: May 11, 2020
• Est. completion date: June 1, 2021

Study information

• Verified date: June 2021
• Source: Helsinki University Central Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Will the use of a clinical decision algorithm in the ED improve discharge or admission decisions.

Description:

Background Crowding and readmissions are common challenges in Emergency departments across Europe. The decision whether to admit or discharge the patient is challenging and is often based on clinical signs and symptoms e.g. blood pressure, pulse, respiratory rate, oxygen saturation and temperature. But some patients are unnecessarily admitted and may have been better off if sent home. Other patients may be discharged without - and one out of five patients are readmitted within a month raising the question whether the patient should have been admitted at first presentation in the ED. suPAR is a strong prognostic biomarker measured routinely in acute medical patients in some emergency department (ED) settings.suPAR is a broadly applicable biomarker of risk, and it has been developed an algorithm for simple interpretation of suPAR in clinical decisions for the study.

Objective To evaluate the use of a clinical decision algorithm in the ED with the aim of improving discharge or admission decisions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1800
• Est. completion date: June 1, 2021
• Est. primary completion date: June 1, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 104 Years

Eligibility

Inclusion Criteria:

• All patients above 18 years

• who are having blood taken for biochemical analysis when attending the ED

Exclusion Criteria:

• Acute medical patients that do not have blood drawn for routine biochemical testing.

• Pregnant

• Under 18 years old

• Terminally ill patients.

Related Conditions & MeSH terms

• Critical Illness

Intervention

Diagnostic Test:
• suPAR algoritm
All medical patients attending to the ED and who will have blood drawn for routine examination will be part of the study. In patients with low suPAR (green group, suPAR below 3 ng/ml) and in patients with high suPAR (red group, suPAR > 6 ng/mL) the Intervention will be carried out

Locations

Country	Name	City	State
Finland	Department of Emergency Medicine and Services, Helsinki University Hospital and Helsinki University, Helsinki, Finland	Helsinki	Helsinki Usimaa

Sponsors (2)

Lead Sponsor	Collaborator
Helsinki University Central Hospital	University of Copenhagen

Country where clinical trial is conducted

Finland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Economical savings	Amount of money	30 days
Primary	Discharges	Number of discharges from the ED within 24 hours	30 days
Secondary	Admissions	Number of admissions to hospital	30 days
Secondary	Length of stay	Length of stay during admission	30 days
Secondary	Readmissions	Number of readmissions	1,7 and 30 days
Secondary	Mortality	Number of Mortality	30 days