Relationship Between Muscle Strength and Physical Function in ICU

Critical Illness Clinical Trial

Official title:

Analysis of the Relationship Between Muscle Strength and Physical Function in ICU Survivors

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04284475
• Other study ID #: MSF
• Status: Completed
• Start date: October 1, 2018
• Est. completion date: November 1, 2021

Study information

• Verified date: November 2021
• Source: University of Liege
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This observational study aims to assess the relationship between muscle strength and physical function in critical ill patients. Grip and quadriceps strengths are measured using a standardized protocol of dynamometry. Physical function is assessed using the validated ICU mobility scale.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 93
• Est. completion date: November 1, 2021
• Est. primary completion date: December 31, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• ICU stay of at least 48h

• Collaborative (RASS score -1 to +1)

Exclusion Criteria:

• Refusal

• Coma

• Non collaborative

• Hemi / tetra paresis or plegia

Related Conditions & MeSH terms

• Critical Illness
• Muscle Weakness
• Physical Dependence
• Physical Disability

Intervention

Diagnostic Test:
• Quadriceps strength
Using a handheld dynamometer, in supine position in a standardized position of the dominant leg Measurement of the maximal isometric voluntary quadriceps contraction Measure expressed as Newton and Newton/kg
• Grip strength
Testing of dominant hand using a handgrip Measurement of the maximal isometric voluntary grip contraction Measure is expressed as kg
• ICU mobility scale
Scoring the physical capacity of the patient on a 10-points validated scale: the ICU mobility scale

Locations

Country	Name	City	State
Belgium	University Hospital of Liège	Liège

Sponsors (1)

Lead Sponsor	Collaborator
University of Liege

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Quadriceps strength	Quadriceps maximal isometric strength measured using dynamometry	as soon as collaborative during ICU stay and up to 1 month following ICU discharge
Primary	Handgrip strength	Grip maximal isometric strength measured using dynamometry	as soon as collaborative during ICU stay and up to 1 month following ICU discharge
Primary	ICU mobility scale	Ranking the patient on the scale according to his/her physical capacity. ICU mobility scale is a 10 points scale: 0 means the patient is lying in bed, 10 means the patient is able to walk independently	as soon as collaborative during ICU stay and up to 1 month following ICU discharge