Critical Illness Clinical Trial
— RE-CCIPOfficial title:
Platelet Transfusion Efficacy in Critically Ill Patients
Between 10 and 15% of critically ill patients require platelet transfusion within their
intensive care unit (ICU).
Platelets (PLT) are given to prevent bleeding in thrombocytopenic patients or to treat
bleeding as part of massive transfusion or in bleeding thrombocytopenic patients.
International and local guidelines (American Association of Blood Banks-AABB) are mainly
based on experts' opinion. The efficacy of PLT transfusion in the ICU setting remains poorly
studied and unknown and the administration of PLT may be associated with adverse effects
including an increased risk of hospital acquired infection. Finally, the short PLT
shelve-life may be responsible for inventory issues. Altogether, this makes very important to
improve the evidence that support PLT transfusion in ICU patients.
This is a multicentre prospective observational study that aims to first determine PLT
transfusion efficacy and to identify the parameters associated with transfusion efficacy and
to analyse the compliance with international (and local) guidelines of PLT transfusion in ICU
patients.
Status | Recruiting |
Enrollment | 300 |
Est. completion date | December 15, 2019 |
Est. primary completion date | December 15, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patients admitted to intensive care and receiving at least one platelet transfusion in intensive care unit Exclusion Criteria: - Age less than 18 |
Country | Name | City | State |
---|---|---|---|
France | CHU d'Angers | Angers | |
France | CHRU de Brest | Brest | |
France | CH des Pays de Morlaix | Morlaix | |
France | CHU de Nantes | Nantes | |
France | CHU de Rennes | Rennes | |
France | CHU de Tours | Tours | |
France | Chba Site de Vannes | Vannes |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Brest |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | platelet transfusion efficacy | corrected count platelet increment | between 18 hours and 28 days after transfusion |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04551508 -
Delirium Screening 3 Methods Study
|
||
Recruiting |
NCT06037928 -
Plasma Sodium and Sodium Administration in the ICU
|
||
Completed |
NCT03671447 -
Enhanced Recovery After Intensive Care (ERIC)
|
N/A | |
Recruiting |
NCT03941002 -
Continuous Evaluation of Diaphragm Function
|
N/A | |
Recruiting |
NCT04674657 -
Does Extra-Corporeal Membrane Oxygenation Alter Antiinfectives Therapy Pharmacokinetics in Critically Ill Patients
|
||
Completed |
NCT04239209 -
Effect of Intensivist Communication on Surrogate Prognosis Interpretation
|
N/A | |
Completed |
NCT05531305 -
Longitudinal Changes in Muscle Mass After Intensive Care
|
N/A | |
Terminated |
NCT03335124 -
The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock
|
Phase 4 | |
Completed |
NCT02916004 -
The Use of Nociception Flexion Reflex and Pupillary Dilatation Reflex in ICU Patients.
|
N/A | |
Recruiting |
NCT05883137 -
High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
|
||
Completed |
NCT04479254 -
The Impact of IC-Guided Feeding Protocol on Clinical Outcomes in Critically Ill Patients (The IC-Study)
|
N/A | |
Recruiting |
NCT04475666 -
Replacing Protein Via Enteral Nutrition in Critically Ill Patients
|
N/A | |
Not yet recruiting |
NCT04516395 -
Optimizing Antibiotic Dosing Regimens for the Treatment of Infection Caused by Carbapenem Resistant Enterobacteriaceae
|
N/A | |
Not yet recruiting |
NCT04538469 -
Absent Visitors: The Wider Implications of COVID-19 on Non-COVID Cardiothoracic ICU Patients, Relatives and Staff
|
||
Withdrawn |
NCT04043091 -
Coronary Angiography in Critically Ill Patients With Type II Myocardial Infarction
|
N/A | |
Recruiting |
NCT02922998 -
CD64 and Antibiotics in Human Sepsis
|
N/A | |
Recruiting |
NCT02989051 -
Fluid Restriction Keeps Children Dry
|
Phase 2/Phase 3 | |
Completed |
NCT02899208 -
Can an Actigraph be Used to Predict Physical Function in Intensive Care Patients?
|
N/A | |
Completed |
NCT03048487 -
Protein Consumption in Critically Ill Patients
|
||
Recruiting |
NCT02163109 -
Oxygen Consumption in Critical Illness
|