Critical Illness Clinical Trial
Official title:
Platelet Transfusion Efficacy in Critically Ill Patients
Between 10 and 15% of critically ill patients require platelet transfusion within their
intensive care unit (ICU).
Platelets (PLT) are given to prevent bleeding in thrombocytopenic patients or to treat
bleeding as part of massive transfusion or in bleeding thrombocytopenic patients.
International and local guidelines (American Association of Blood Banks-AABB) are mainly
based on experts' opinion. The efficacy of PLT transfusion in the ICU setting remains poorly
studied and unknown and the administration of PLT may be associated with adverse effects
including an increased risk of hospital acquired infection. Finally, the short PLT
shelve-life may be responsible for inventory issues. Altogether, this makes very important to
improve the evidence that support PLT transfusion in ICU patients.
This is a multicentre prospective observational study that aims to first determine PLT
transfusion efficacy and to identify the parameters associated with transfusion efficacy and
to analyse the compliance with international (and local) guidelines of PLT transfusion in ICU
patients.
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