Critical Illness Clinical Trial
Official title:
Preventing Acute Kidney Injury and Improving Outcome in Critically Ill Patients Utilising Risk Prediction Score - a Pilot Feasibility Randomized Controlled Trial
An interventional controlled trial to test the feasibility of applying risk score based prevention for critically ill patient at high risk to develop acute kidney injury (AKI)
Background and rationale AKI is common in the intensive care unit .It contributes
significantly to mortality and morbidity .the estimated incidence or AKI among critically ill
patients is 30-40% and morality is high.
There is a well recognized gap between the optimal care and the delivered care regarding
prevention and management of AKI.
The focus over the last few years has been on early detection. A panel of urinary biomarkers
have proved helpful for early detection of AKI. However the cost and low specificity make no
single one of them solely reliable .using a panel of bio-markers increases their specificity.
The concept of electronic alerts has been recently introduced. Some trials have been testing
its impact on the outcome of AKI. The benefit of electronic alerts is still uncertain .A
meta-analysis is currently underway to synthesize stronger evidence of electronic alerts
benefit.
Another evolving area, is the development of risk score to predict AKI and and hence applying
timely preventive measures.
KDIGO recommends applying preventive measures to high risk patients. However no study to date
has tested risk scores based interventions
Hypothesis:
We will use the recently validated score to predict AKI in ICU patients. We will then apply
preventive measures. To patients at risk .To our knowledge this is the first study to apply
preventive interventions based on AKI risk score assessment
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