Critical Illness Clinical Trial
Official title:
Combining Two Commonly Adopted Nutrition Instruments in the Critical Care Setting is Superior to Administering Either One Alone
There are two nutrition assessment tools that are commonly used in the ICU, namely the
Subjective Global Assessment (SGA) and Modified Nutrition Risk in Critically Ill Score
(mNUTRIC). It has been proposed that both assessments should be performed in the ICU but
their combined prognostic ability has not been adequately assessed.
This study aimed to: 1) determine the agreement between SGA and mNUTRIC scores, and 2)
quantify their utility in discriminating and quantifying hospital mortality risk both
independently and in combination.
This prospective observational study will be conducted in a 35-bed mixed ICU in Ng Teng Fong
General Hospital, and all the intensivists and nurses will be blinded to the objectives of
the study. All patients admitted to the ICU will be consecutively included in the study. For
patients readmitted to the ICU during the same hospitalisation, only data from the first
admission will be collected.
As per routine care, all patients will have their nutritional status assessed by the
dietitian within 48 hours of ICU admission. Information required for the nutritional
assessment (SGA) will be obtained from the patients or their main care givers, and
nutritional status will be dichotomized into well-nourished and malnourished.
The electronic medical records automatically and prospectively collects all data required to
calculate the mNUTRIC. At the end of the study, the mNUTRIC will be retrospectively
calculated. Patients with values of "0-4" will be classified as low-mNUTRIC and "5-9" as
high-mNUTRIC.
The primary outcome will be hospital mortality and all patients will be followed until
discharge or death, for up to one year after admission to the ICU.
Agreement and mortality discriminative value (i.e. discrimination) of the 2-category
classification of mNUTRIC (Low- and high-mNUTRIC) and SGA (SGA-A and SGA-B/C) will be
assessed by Kappa statistics and C-statistics respectively.
A multivariate logistic regression will be used to generate the adjusted odds ratios that
quantify the association between high-mNUTRIC, malnutrition, and their combination (mNUTRIC
≥ 5 and SGA-B/C) with hospital mortality.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04551508 -
Delirium Screening 3 Methods Study
|
||
| Recruiting |
NCT06037928 -
Plasma Sodium and Sodium Administration in the ICU
|
||
| Completed |
NCT03671447 -
Enhanced Recovery After Intensive Care (ERIC)
|
N/A | |
| Recruiting |
NCT03941002 -
Continuous Evaluation of Diaphragm Function
|
N/A | |
| Recruiting |
NCT04674657 -
Does Extra-Corporeal Membrane Oxygenation Alter Antiinfectives Therapy Pharmacokinetics in Critically Ill Patients
|
||
| Completed |
NCT04239209 -
Effect of Intensivist Communication on Surrogate Prognosis Interpretation
|
N/A | |
| Completed |
NCT05531305 -
Longitudinal Changes in Muscle Mass After Intensive Care
|
N/A | |
| Terminated |
NCT03335124 -
The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock
|
Phase 4 | |
| Completed |
NCT02916004 -
The Use of Nociception Flexion Reflex and Pupillary Dilatation Reflex in ICU Patients.
|
N/A | |
| Recruiting |
NCT05883137 -
High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
|
||
| Completed |
NCT04479254 -
The Impact of IC-Guided Feeding Protocol on Clinical Outcomes in Critically Ill Patients (The IC-Study)
|
N/A | |
| Recruiting |
NCT04475666 -
Replacing Protein Via Enteral Nutrition in Critically Ill Patients
|
N/A | |
| Not yet recruiting |
NCT04538469 -
Absent Visitors: The Wider Implications of COVID-19 on Non-COVID Cardiothoracic ICU Patients, Relatives and Staff
|
||
| Not yet recruiting |
NCT04516395 -
Optimizing Antibiotic Dosing Regimens for the Treatment of Infection Caused by Carbapenem Resistant Enterobacteriaceae
|
N/A | |
| Withdrawn |
NCT04043091 -
Coronary Angiography in Critically Ill Patients With Type II Myocardial Infarction
|
N/A | |
| Recruiting |
NCT02922998 -
CD64 and Antibiotics in Human Sepsis
|
N/A | |
| Recruiting |
NCT02989051 -
Fluid Restriction Keeps Children Dry
|
Phase 2/Phase 3 | |
| Completed |
NCT02899208 -
Can an Actigraph be Used to Predict Physical Function in Intensive Care Patients?
|
N/A | |
| Completed |
NCT03048487 -
Protein Consumption in Critically Ill Patients
|
||
| Recruiting |
NCT02163109 -
Oxygen Consumption in Critical Illness
|