Critical Illness Clinical Trial
Official title:
SC2i VIPER: EnVenomation Investigation Pilot to Evaluate Recovery
The purpose of this study is to pilot data for a systematic molecular characterization of pathophysiologic perturbations incurred by snake envenomation and compare this to other inflammatory physiologic states such as trauma and sepsis. This sub-study will analyze samples of participants enrolled under the parent study "Surgical Critical Care Initiative Tissue and Data Acquisition Protocol".
The goal of this study is to pilot data for a systematic molecular characterization of
pathophysiologic perturbations incurred by snake envenomation and compare this to other
inflammatory physiologic states such as trauma and sepsis. The investigators will
characterize transcriptomic and immune biomarker response to varying clinical severities of
snakebite envenomation and compare to that of sepsis and traumatic injury.
This sub-study will analyze samples of participants enrolled under a previously IRB-approved
protocol, "Surgical Critical Care Initiative Tissue and Data Acquisition Protocol (SC2i
TDAP)". All participants eligible for protocol SC2i TDAP (NCT 02182180) are eligible to be
included in the current proposal, and conversely, the investigators will not enroll any
participants in the current protocol who is not enrolled in SC2i TDAP. Participants enrolled
under that protocol who have suffered snakebite envenomation will undergo additional
procedure of follow up phone call 3, 7, 14, 21 and 28 days after discharge from the emergency
department or hospital to fill out the PSFS via phone. All labs and other procedures will
otherwise be as described in SC2i TDAP.
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