Critical Illness Clinical Trial
Official title:
Alterations of Glycocalyx in Critical Illness and During Major Surgery and Approaches for Glycocalyx Protection
The hypothesis to be tested: GCX damage and its dynamics correlate to various patient related
factors and to using organ-supporting measures. There is a correlation between length of
organ support and GCX damage.
The aim of the study: Evaluation of the relationship between GCX damage and duration of
various organ supporting measures.
Type of the study: Observational. Subjects: Adult patients admitted to ICU and requiring
organ supporting therapy.
Sample size: We plan enrollment of 75 patients on invasive ventilatory support in the
duration of least 5 days, 50 patients on renal supporting therapy lasting at least 5 days and
20 patients with target temperature management for neuroprotection.
Intervention: none Data to be recorded and analysed: Demographics, type of patients (trauma,
post surgical, medical, after cardiac arrest), severity score - Apache II, SOFA, fluid
balance, presence of delirium, clinical outcome, sublingual microcirculation by SDF imaging
at time points: before or at the start of organ support, after 24 hours (day 1), day 3, 5, 7
and/or at discharge or before death, microcirculatory data, and Perfused Boundary Region.
n/a
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