Critical Illness Clinical Trial
Official title:
Effect of High Dose Vitamin D3 Supplementation on Skeletal Muscle Mass and Body Compositions in Critically Ill Patients With Vitamin D Deficiency
A randomized double blind placebo control trial study will be conducted in critically ill patients with vitamin D deficiency. Investigator aimed to study the effect of oral vitamin D3 supplementation, compare to placebo, on skeletal muscle mass and body composition.
There is a high prevalence of vitamin D deficiency in critically ill patient which is
associated with muscle wasting and physical disability. Recent study showed that treatment
of vitamin D deficiency with high dose vitamin D improved muscle wasting and may prevent
further muscle breakdown.
Investigator want to explore whether a high dose vitamin D3 supplementation, compare to
placebo will be able to improve muscle wasting in critically ill patients.
The eligible participant will be asked to sign and date the informed consent document then
they will be randomized to receive vitamin D3 supplement or placebo, using the computer
generated code in conceal envelope.
Vitamin D3 or placebo will be given orally or feeding tube via feeding tube at a dose of
100,000 IU on day 1 and 3 then 50,000 IU on day 5,7,9,12 followed by 150,000 unit per week
for 4 week.
Serum 25-Hydroxyvitamin D, 1,25-dihydroxyvitamin D will be measured at baseline (day 0) then
day 10 and day 43 after vitamin D supplementation. Moreover, Investigator will assess the
diameter of rectus femoris by using ultrasonography on day 0,10 and 43.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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