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Evaluation of Intestinal Brush Border Enzyme Function in Critically Ill Patients

Critical Illness Clinical Trial

Official title:
Evaluation of Intestinal Brush Border Enzyme Function in Patients With SIRS and Septic Shock Compared to Control Patients

Clinical Trial Summary

The purpose of this study is to evaluate the role of several enzymes of the gut mucosa in preventing invasion of gastrointestinal bacteria.

Clinical Trial Description

Systemic Inflammatory Response Syndrome (SIRS), sepsis, septic shock and concomitant multiorgan failure are major causes of morbidity and mortality in intensive care units. During SIRS and septic shock the role of the gut seems to be uncertain. As it serves as an intestinal barrier which allows the symbiotic relationship between man and enteric bacteria, increased gut permeability during critical illness is accused to promote sepsis. Brush border enzymes have the ability to detoxify lipopolysaccharides and prevent bacterial invasion across the gut mucosal barrier. A reduced brush border enzyme function could contribute to the gastrointestinal intolerance in critically ill patients, which is frequently observed. The aim of this study is to assess the influence of SIRS and septic shock on brush border enzyme morphology and function in men. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01585909
Study type Interventional
Source Medical University of Vienna
Contact
Status Completed
Phase N/A
Start date July 2011
Completion date September 2015
View Details
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