Critical Illness Clinical Trial
Official title:
Incidence and Prognostic Significance of Intraabdominal Pressure in Critically Ill Patients
This study is conducted to evaluate the incidence and prognostic significance of IAH in medical ICU patients.
Increased Intra-abdominal pressure (IAP) is an important cause of morbidity and mortality in
ICU patients with consequent pulmonary, hepatic, central nervous and renal system
impairments.
The increase in IAP is rarely diagnosed in ICU and the lack of diagnosis of this condition
may lead to the worsening of patient prognoses because of retardation of appropriate
interventions .
The current literatures show conflicting cutoff values of IAP that predict AKI, possibly due
to the fact that many studies were conducted before publishing of the first Consensus of
IAH/ACS, which standardized the measurement method of IAP.
Intra-abdominal hypertension is defined as a sustained or repeated pathologic elevation of
intra-abdominal pressure greater than 12 mmHg [Malbrain et al 2004, cheathamML et al 2007].
Intra-abdominal hypertension is graded as follows:
- Grade I Intra-abdominal pressure 12-15 mmHg.
- Grade II Intra-abdominal pressure 16-20 mmHg.
- Grade III Intra-abdominal pressure 21-25 mmHg.
- Grade IV Intra-abdominal pressure greater than 25 mmHg Various risk factors contribute
to the development of IAH in medical ICU including; massive fluid resuscitation (> 3500
ml/24 h), ileus, respiratory, renal, or liver dysfunction, hypothermia, acidosis,
anemia, oliguria, and hyperlactatemia .
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